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SYMPOSIUM 2016

PROJECTS 2nd FUNDING PERIOD

A01: Selection of allo-restricted peptide-specific T cells for adoptive therapy of acute leukaemia
A02: Transgenic mice with a human T cell receptor repertoire
A03: Use of peptide libraries to improve the generation of effector and helper T cells from naïve and immunosuppressed patients for adoptive T cell therapy - CMV as a model
A04: EBV/CMV-bispecific T cells for adoptive therapy
A10: Immunological in-depth characterisation of human donor-derived CMV-specific CD8+ T cells for adoptive T cell therapy
A11: "Versatile memory T cells" for adoptive T cell therapy - identification, characterisation and strategies for clinical applications
A12: RNAi-based replacement of the endogenous by a therapeutic T cell receptor
A13: Improved MHC multimer-based single cell analyses for the identification of TCR sequences with "optimal high avidity" for immunotherapy
B01: Tumour stroma cells as a target of adoptively transferred T cells
B02: Adoptive T cell therapy of tumours visualised by non-invasive in vivo imaging
B05: Effector and regulatory CD4 T cells in tumour surveillance
B07: Regulation of homeostatic T cell proliferation
B09: Adoptive T cell therapy to treat hepatocellular carcinoma
B10: Adoptive T cell therapy against tumours with defects in the antigen processing machinery
Z01: Core facility for the construction and characterisation of T cell receptor gene-modified T lymphocytes
Z02: Histomorphological analysis of T cells and the microenvironment in situ
Z03: Platform for clinical application of TCR-engineered T cells with defined specificity
V01: Administration of the SFB TR36 and coordination of activities




General information about Project A01:

Title: Selection of allo-restricted peptide-specific T cells for adoptive therapy of acute leukaemia

Research areas: Immunology, Immunotherapy

Principal investigators:
Prof. Schendel, Dolores J., Ph.D.
Institut für Molekulare Immunologie
Helmholtz Zentrum München
Marchioninistr. 25, 81377 München
Telefon:+49 (0)89 7099 301
Telefax: +49 (0)89 7099 300
E-Mail: schendel@helmholtz-muenchen.de

Dr. rer. nat. Frankenberger, Bernhard
Institut für Molekulare Immunologie
Helmholtz Zentrum München
Marchioninistr. 25, 81377 München
Telefon:+49 (0)89 7099 344
Telefax: +49 (0)89 7099 300
E-Mail: b.frankenberger@helmholtz-muenchen.de
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General information about Project A02:

Title: Transgenic mice with a human T cell receptor repertoire

Research areas: Immunology, Tumour Immunology

Principal investigator:
Prof. Dr. rer. nat. Blankenstein, Thomas
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 3639
Telefax: +49 (0)30 8445 4613
E-Mail: thomas.blankenstein@charite.de

and:
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon: +49 (0)30 9406 2310
Telefax: +49 (0)30 9406 2453
E-mail:tblanke@mdc-berlin.de
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General information about Project A03

Title: Use of peptide libraries to improve the generation of effector and helper T cells from naïve and immunosuppressed patients for adoptive T cell therapy - CMV as a model

Research areas: Clinical Immunology, Virology, Transplantation

Principal investigators:
Prof. Dr. med. Volk, Hans-Dieter
Inst. Med. Immunology, CCM, and Berlin-Brandenburg
Center for Regenerative Therapies (BCRT), CVK,
Charité Universitätsmedizin Berlin
Charitéplatz 1, 10117 Berlin
Telefon: +49 (0)30 450 524062
Telefax: +49 (0)30 450 524932
E-Mail: hans-dieter.volk@charite.de

Prof. Dr. med. Reinke, Petra
Dept. of Nephrology and Internal Intensive Medicine,
CVK, and Berlin-Brandenburg Center for Regenerative
Therapies (BCRT), CVK,
Charité Universitätsmedizin Berlin,
Augustenburger Platz 1, 13353 Berlin
Telefon: +49 (0)30 450 653490
Telefax: +49 (0)30 450 553916
E-Mail: petra.reinke@charite.de
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General information about Project A04

Title: EBV/CMV-bispecific T cells for adoptive therapy

Research areas: Immunology, Immunotherapy

Principal investigators:
Dr. rer. nat. Moosmann, Andreas
Klinische Kooperationsgruppe Molekulare Onkologie
Klinikum der Universität München
Marchioninistraße 25, 81377 München
Telefon: +49 (0)89 7099 202
Telefax: +49 (0)89 7099 225
E-Mail: andreas.moosmann@helmholtz-muenchen.de

Prof. Dr. med. vet. Hammerschmidt, Wolfgang
Abteilung Genvektoren
Helmholtz Zentrum München
Marchioninistraße 25, 81377 München
Telefon: +49 (0)89 3187 1506
Telefax: +49 (0)89 3187 19 1506
E-Mail: hammerschmidt@helmholtz-muenchen.de
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General information about Project A10

Title: Immunological in-depth characterisation of human donor-derived CMV-specific CD8+ T cells for adoptive T cell therapy

Research areas: Immunology, Immunotherapy

Principal investigators:
Dr. med. Neuenhahn, Michael
Institut für Mikrobiologie, Immunologie und Hygiene
Technische Universität München
Trogerstr. 30, 81675 München
Telefon: +49 (0)89 4140 7454
Telefax: +49 (0)89 4140 4131
E-Mail:michael.neuenhahn@mikrobio.med.tum.de

Prof. Dr. med. Busch, Dirk
Institut für Mikrobiologie, Immunologie und Hygiene
Technische Universität München
Trogerstr. 30, 81675 München
Telefon: +49 (0)89 4140 4120
Telefax: +49 (0)89 4140 4868
E-Mail: dirk.busch@mikrobio.med.tum.de
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General information about Project A11

Title: "Versatile memory T cells" for adoptive T cell therapy - identification, characterisation and strategies for clinical applications

Research areas: Immunology, Immunotherapy

Principal investigators:
Prof. Dr. rer. nat. Thiel, Andreas
Regenerative Immunology and Aging
Berlin-Brandenburg Centre for Regenerative Therapies (BCRT)
Charité Universitätsmedizin Berlin
Föhrer Str. 15, 13353 Berlin
Telefon: +49 (0)30 450539 555
Telefax: +49 (0)30 450539 595
E-Mail: andreas.thiel@charite.de

Prof. Dr. rer. nat. Radbruch, Andreas
Cell Biology
Deutsches Rheuma-Forschungszentrum (DRFZ)
Charitéplatz 1, 10117 Berlin
Telefon: +49 (0)30 28460 600
Telefax: +49 (0)30 28460 603
E-Mail: radbruch@drfz.de
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General information about Project A12

Title: RNAi-based replacement of the endogenous by a therapeutic T cell receptor

Research areas: Immunology, Immunotherapy, Gene Therapy

Principal investigator:
Prof. Dr. rer. nat. Uckert, Wolfgang
Institut für Biologie
Humboldt-Universität zu Berlin and
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon:+49 (0)30 9406 3196
Telefax: +49 (0)30 9406 3306
E-Mail: wuckert@mdc-berlin.de
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General information about Project A13

Title: Improved MHC multimer-based single cell analyses for the identification of TCR sequences with "optimal high avidity" for immunotherapy

Research areas: Immunology, Immunotherapy

Principal investigator:
Prof. Dr. med. Busch, Dirk H.
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Technische Universität München
Trogerstr. 30, 81675 München
Telefon: +49 (0)89 4140 4120
Telefax: +49 (0)89 4140 4868
E-Mail: dirk.busch@mikrobio.med.tum.de
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General information about Project B01

Title: Tumour stroma cells as a target of adoptively transferred T cells

Research areas: Immunology, Tumour Immunology

Principal investigators:
Dr. rer. nat. Kammertöns, Thomas
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 3639
Telefax: +49 (0)30 8445 4613
E-Mail: thomas.kammertoens@charite.de

PD Dr. rer. nat. Nößner, Elfriede
Institut für Molekulare Immunologie
Helmholtz Zentrum München
Marchioninistraße 25, 81377 München
Telefon: +49 (0)89 7099 303
Telefax: +49 (0)89 7099 300
E-Mail: noessner@helmholtz-muenchen.de
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General information about Project B02

Title: Adoptive T cell therapy of tumours visualised by non-invasive in vivo imaging

Research areas: Immunology, Tumour Immunology

Principal investigators:
Dr. Charo, Jehad, Ph.D.
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Str. 10, 13092 Berlin
Telefon: +49 (0)30 9406 2687
Telefax: +49 (0)30 9406 2453
E-Mail:j.charo@mdc-berlin.de

Prof. Dr. rer. nat. Blankenstein, Thomas
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 3639
Telefax: + 49 (0)30 8445 4613
E-Mail: thomas.blankenstein@charite.de

and:
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon: + 49 (0)30 9406 2310
Telefax: + 49 (0)30 9406 2453
E-Mail: tblanke@mdc-berlin.de
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General information about Project B05

Title: Effector and regulatory CD4 T cells in tumour surveillance

Research areas: Immunology, Oncology, Immunotherapy

Principal investigators:
Dr. Fillatreau, Simon, Ph.D.
Deutsches Rheuma-Forschungszentrum (DRFZ)
Arbeitsgruppe Immunregulation
Charitéplatz 1, 10117 Berlin
Telefon: +49 (0)30 28460 752
Telefax: +49 (0)30 28460 603
E-Mail: fillatreau@drfz.de

Dr. med. Romagnani, Chiara, Ph.D.
Deutsches Rheuma-Forschungszentrum (DRFZ)
Arbeitsgruppe Angeborene Immunität
Charitéplatz 1, 10117 Berlin
Telefon: +49 (0)30 28460 681
Telefax: +49 (0)30 28460 603
E-Mail: romagnani@drfz.de
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General information about Project B07

Title: Regulation of homeostatic T cell proliferation

Research areas: T Cell Homeostasis, Tumour Immunology

Principal investigator:
Prof. Dr. rer. nat. Schüler, Thomas
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 4020
Telefax: +49 (0)30 8445 4613
E-Mail: thomas.schueler@charite.de
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General information about Project B09

Title: Adoptive T cell therapy to treat hepatocellular carcinoma

Research areas: Immunology, Tumour Immunology, Virology

Principal investigators:
Dr. rer. nat. Willimsky, Gerald
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 4607
Telefax: +49 (0)30 8445 4613
E-Mail: gerald.willimsky@charite.de

PD Dr. Heikenwälder, Mathias, Ph.D.
Institut für Virologie
Helmholtz Zentrum München/Technische Universität München

Trogerstrasse 30, 81675 München
Telefon: +49 (0)89 7099 362
Telefax: +49 (0)89 7099 300
E-Mail: mathias.heikenwaelder@helmholtz-muenchen.de

Prof. Dr. med. Zeitz, Martin
Medizinische Klinik I
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 2347
Telefax: +49 (0)30 8445 4481
E-Mail: martin.zeitz@charite.de
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General information about Project B10

Title: Adoptive T cell therapy against tumours with defects in the antigen processing machinery

Research areas: Immunology, Biochemistry

Principal investigator:
Dr. med. Seifert, Ulrike
Institut für Biochemie
Charité-Universitätsmedizin Berlin, CCM
Oudenarder Str. 16, 13347 Berlin
Telefon: +49 (0)30 450 528186
Telefax: +49 (0)30 450 528921
E-Mail: ulrike.seifert@charite.de
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General information about Project Z01

Title: Core facility for the construction and characterisation of T cell receptor gene-modified T lymphocytes

Research areas: Tumour Immunology, Gene Therapy

Principal investigators:
Prof. Dr. rer. nat. Uckert, Wolfgang
Institut für Biologie
Humboldt-Universität zu Berlin
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon:+49 (0)30 9406 3196
Telefax: +49 (0)30 9406 3306
E-Mail: wuckert@mdc-berlin.de

Prof. Dr. Schendel, Dolores J., Ph.D.
Institut für Molekulare Immunologie
Helmholtz Zentrum München
Marchioninistraße 25, 81377 München
Telefon: +49 (0)89 7099 301
Telefax: +49 (0)89 7099 300
E-Mail: schendel@helmholtz-muenchen.de
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General information about Project Z02

Title: Histomorphological analysis of T cells and the microenvironment in situ

Research areas: Histopathology, Immunopathology, Tumour pathology

Principal investigator:
Prof. Dr. med. Loddenkemper, Christoph
Institut für Allgemeine Pathologie und Pathologische Anatomie
Technische Universität München
Klinikum r.d. Isar
Ismaninger Straße 22, 81675 München
Telefon:+49 (0)89 4140 4173
Telefax: +49 (0)89 4140 6106
E-Mail: christoph.loddenkemper@lrz.tum.de
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General information about Project Z03

Title: Platform for clinical application of TCR-engineered T cells with defined specificity

Research areas: Immunology, Haematology, Oncology

Principal investigators:
Prof. Dr. med. Uharek, Lutz
Abteilung für Hämatologie und Onkologie
Campus Benjamin Franklin
Charité - Universitätsmedizin Berlin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0) 30 8445 4550
Telefax: +49 (0) 30 8445 2190
E-Mail: lutz.uharek@charite.de

Prof. Dr. med. Kolb, Hans Jochem
III. Medizinische Klinik
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Str. 22, 81675 München
Telefon: +49 (0) 89 7095 4240
Telefax: +49 (0) 89 7095 4242
E-Mail: hans.kolb@med.uni-muenchen.de
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General information about Project V01

Title: Administration of the SFB TR36 and coordination of activities

Spokesperson:
Prof. Dr. rer. nat. Blankenstein, Thomas
Institut für Immunologie
Charité Campus Benjamin Franklin
Hindenburgdamm 30, 12200 Berlin
Telefon: +49 (0)30 8445 3639
Telefax: + 49 (0)30 8445 4613
E-Mail: thomas.blankenstein@charite.de

and:
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon: + 49 (0)30 9406 2310
Telefax: + 49 (0)30 9406 2453
E-Mail: tblanke@mdc-berlin.de
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SFB Office Berlin: Anette Madel
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon:+49 (0)30 9406 3307
Telefax: +49 (0)30 9406 3306
E-Mail: anette.madel@mdc-berlin.de
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Deputies Spokespersons:
Prof. Dr. Schendel, Dolores J., Ph.D.
Helmholtz Zentrum München
Institut für Molekulare Immunologie
Marchioninistr. 25, 81377 München
Telefon: +49 (0)89 7099 301
Telefax: +49 (0)89 7099 300
E-mail: schendel@helmholtz-muenchen.de

Prof. Dr. rer. nat. Uckert, Wolfgang
Humboldt-Universität zu Berlin
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Straße 10, 13092 Berlin
Telefon: +49 (0)30 9406 3196
Telefax: +49 (0)30 9406 3306
E-Mail: wuckert@mdc-berlin.de
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SFB Office München
Angela Hoffmann
Helmholtz Zentrum München
Marchioninistr. 25, 81377 München
Telefon: +49 (0)89 7099 301
Telefax: +49 (0)89 7099 300
E-mail: angela.hoffmann@helmholtz-muenchen.de
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SFB TR36 - Charité-Universitätsmedizin Berlin
Prof. Dr. Thomas Blankenstein
Institute of Immunology
Lindenberger Weg 80
13125 Berlin

SFB TR36 -Technische Universität München
Prof. Dr. Dirk Busch
Institute for Medical Microbiology, Immunology and Hygiene
Trogerstraße 30
81675 München