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SYMPOSIUM 2016

PROJECTS 3rd FUNDING PERIOD

A02: Transgenic mice with a human T cell receptor repertoire
A03: Use of peptide libraries to improve the generation of effector and helper T cells from immunosuppressed patients for adoptive T-cell therapy - HCMV as a model
A04: EBV/CMV bi-specific T cells for adoptive therapy
A10: Immunological characterization of human donor-derived pathogen-specific T cells for adoptive T cell therapy
A11: "Versatile memory T cells" for adoptive T cell therapy - identification, characterization and strategies for clinical applications
A12: RNAi-based replacement of endogenous by a therapeutic T cell receptor
A13: Improved MHC multimer-based single cell analyses for the identification of TCR sequences with "optimal high avidity" for immunotherapy
A14: T cell therapy with chimeric antigen receptors (CARs) recognizing hepatitis B surface antigen
T01: Selection of allo-restricted peptide-specific T cells for adoptive therapy of acute leukemia
B02: Adoptive T cell therapy of tumors visualized by non-invasive in vivo imaging
B09: Adoptive T cell therapy to treat hepatocellular carcinoma
B12: Targeting the secretory pathway in T cells to enhance the cytolytic efficiency in adoptive T cell therapy
B13: Molecular mechanisms facilitating improved efficacy of adoptive T cell therapy in the liver
Z01: Core facility for the construction and characterization of T cell receptor gene-modified T lymphocytes
Z03: Platform for clinical application of TCR- and CAR-engineered T cells with defined specificity
V01: Administration of the SFB TR36 and coordination of activities




General information about Project A02

Title: Transgenic mice with a human T cell receptor repertoire

Research areas: Immunology, Cancer Immunology

Principal investigator:
Prof. Dr. rer. nat. Blankenstein, Thomas
Institute of Immunology
Charité Campus Buch
Lindenberger Weg 80, 13125 Berlin
Phone: +49 (0)30 9406 2310
Fax: +49 (0)30 9406 2453
E-Mail tblanke@mdc-berlin.de
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General information about Project A03

Title: Use of peptide libraries to improve the generation of effector and helper T cells from immunosuppressed patients for adoptive T-cell therapy - HCMV as a model

Research areas: Clinical Immunology, Virology, Transplantation Immunology

Principal investigators:
Prof. Dr. med. Volk, Hans-Dieter
Institute for Medical Immunology (IMI), CVK, and Berlin-Brandenburg
Center for Regenerative Therapies (BCRT), CVK,
Charité - Universitätsmedizin Berlin
Föhrer Straße 15, 13353 Berlin
Phone: +49 (0)30 450 524 062
Fax: +49 (0)30 450 524 932
E-Mail: hans-dieter.volk@charite.de

Prof. Dr. med. Reinke, Petra
Department of Nephrology and Internal Intensive Medicine,
CVK, and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), CVK,
Charité - Universitätsmedizin Berlin
Föhrer Straße 15, 13353 Berlin
Phone: +49 (0)30 450 524 062
Fax: +49 (0)30 450 524 932
E-mail: petra.reinke@charite.de
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General information about Project A04

Title: EBV/CMV bi-specific T cells for adoptive therapy

Research areas: Immunology, Virology

Principal investigators:
Dr. rer. nat. Moosmann, Andreas
Clinical Cooperation Group Immuno-Oncology
The University Clinic of Munich
Research Unit Gene Vectors
Helmholtz Center, Munich
Marchioinistraße 25, 81377 Munich
Phone: +49 (0)89 3187 1202
E-Mail: andreas.moosmann@helmholtz-muenchen.de

Prof. Dr. med. vet. Hammerschmidt, Wolfgang
Research Unit Gene Vectors
Helmholtz Center, Munich
Marchioinistraße 25, 81377 Munich
Phone: +49 (0)89 3187 1506
E-Mail: hammerschmidt@helmholtz-muenchen.de
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General information about Project A10

Title: Immunological characterization of human donor-derived pathogen-specific T cells for adoptive T cell therapy

Research areas: Immunology, Immunotherapy

Principal investigators:
Dr. med. Neuenhahn, Michael
Institute for Medical Microbiology, Immunology and Hygiene
Technical University of Munich
Trogerstraße 30, 81675 Munich
Phone: +49 (0)89 4140 7454
E-Mail: michael.neuenhahn@tum.de

Prof. Dr. med. Busch, Dirk
Institute for Medical Microbiology, Immunology and Hygiene
Technical University of Munich
Trogerstraße 30, 81675 Munich
Phone: +49 (0)89 4140 4120
E-Mail: dirk.busch@tum.de
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General information about Project A11

Title: "Versatile memory T cells" for adoptive T cell therapy - identification, characterization and strategies for clinical applications

Research areas: Immunology, Immunotherapy

Principal investigators:
Prof. Dr. rer. nat. Thiel, Andreas
Regenerative Immunology and Aging
Berlin-Brandenburg Center for Regenerative Therapies (BCRT), CVK
Charité - Universitätsmedizin Berlin
Föhrer Straße 15, 13353 Berlin
Phone: +49 (0)30 450 539 555
Fax: +49 (0)30 450 539 595
E-Mail: andreas.thiel@charite.de

Prof. Dr. rer. nat. Radbruch, Andreas
Cell Biology
Deutsches Rheuma-Forschungszentrum (DRFZ)
Charitéplatz 1, 10117 Berlin
Phone: +49 (0)30 284 60 600
Fax: +49 (0)30 284 60 603
E-Mail: radbruch@drfz.de
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General information about Project A12

Title: RNAi-based replacement of endogenous by a therapeutic T cell receptor

Research areas: Immunology, Immunotherapy, Gene Therapy

Principal investigator:
Prof. Dr. rer. nat. Uckert, Wolfgang
Institute of Biology
Humboldt University Berlin
Max-Delbrück Center for Molecular Medicine
Robert-Rössle-Straße 10, 13092 Berlin
Phone: +49 (0)30 9406 3196
E-Mail: wuckert@mdc-berlin.de
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General information about Project A13

Title: Improved MHC multimer-based single cell analyses for the identification of TCR sequences with "optimal high avidity" for immunotherapy

Research areas: Immunology, Immunotherapy

Principal investigator:
Prof. Dr. med. Busch, Dirk
Institute for Medical Microbiology, Immunology and Hygiene
Technical University of Munich
Trogerstraße 30, 81675 Munich
Phone: +49 (0)89 4140 4120
E-Mail: dirk.busch@tum.de
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General information about Project A14

Title: T cell therapy with chimeric antigen receptors (CARs) recognizing hepatitis B surface antigen

Research areas: Virology, Immunology

Principal investigator:
Prof. Dr. med. Protzer, Ulrike
Institute of Virology
Technische Universität München
Trogerstraße 30, 81675 Munich
Phone: +49 (0)89 4140 6886
E-Mail: protzer@tum.de
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General information about Project T01

Title: Selection of allo-restricted peptide-specific T cells for adoptive therapy of acute leukemia

Research areas: Immunology, Immunotherapy

Principal investigator:
Dr. rer. nat. Frankenberger, Bernhard
Institute of Molecular Immunology
Helmholtz Center Munich - German Research Center for Environmental Health
Marchioinistraße 25, 81377 Munich
Phone: +49 (0)89 3187 1344
E-Mail: b.frankenberger@helmholtz-muenchen.de

Application partner:
Prof. Dr. Dolores J. Schendel
CSO Medigene/ Managing Director Trianta
Trianta Immunotherapies GmbH
A subsidiary of Medigene AG
Lochhamer Straße 11
D-82152 Planegg-Martinsried
d.schendel@medigene.com
Phone: +49-89-200033-0
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General information about Project B02

Title: Adoptive T cell therapy of tumors visualized by non-invasive in vivo imaging

Research areas: Immunology, Cancer Immunology, Hematology

Principal investigators:
PD Dr. med. Na, Il-Kang
Experimental and Clinical Research Center (ECRC)
Charité Campus Buch
Lindenberger Weg 80, 13125 Berlin
Phone: +49 (0)30 450 540 155
Fax: +49 (0)30 450 540 953
E-Mail: il-kang.na@charite.de

Prof. Dr. rer. nat. Blankenstein, Thomas
Institute of Immunology
Charité Campus Buch
Lindenberger Weg 80, 13125 Berlin
Phone: +49 (0)30 9406 2310
Fax: +49 (0)30 9406 2453
E-Mail tblanke@mdc-berlin.de
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General information about Project B09

Title: Adoptive T cell therapy to treat hepatocellular carcinoma

Research areas: Immunology, Virology, Cancer Immunology

Principal investigators:
Dr. rer. nat. Willimsky, Gerald
Institute of Immunology
Charité Campus Buch
Lindenberger Weg 80, 13125 Berlin
Phone: +49 (0)30 450 513 607
E-Mail: gerald.willimsky@charite.de

Prof. Dr. rer. nat. Heikenwälder, Mathias
Technical University of Munich
Schneckenburgerstraße 8, 81675 Munich
E-Mail: heikenwaelder@virologie.med.tum.de
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General information about Project B12

Title: Targeting the secretory pathway in T cells to enhance the cytolytic efficiency in adoptive T cell therapy

Research areas: Hematology, Cancer Immunology

Principal investigators:
Dr. med. Rehm, Armin
Max-Delbrück-Center for Molecular Medicine
and
Charité - Universitätsmedzin Berlin
Clinic for Internal Medicine, Department of Hematology, Oncology and Tumorimmunology
Robert-Rössle-Straße 10, 13125 Berlin
Phone: +49 (0)30 9406 3817
E-Mail: arehm@mdc-berlin.de

PD Dr. rer. nat. Höpken, Uta Elisabeth
Max-Delbrück-Center for Moleculare Medicine
Robert-Rössle-Straße 10, 13125 Berlin
Phone: +49 (0)30 9406 3330
E-Mail: uhoepken@mdc-berlin.de
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General information about Project B13

Title: Molecular mechanisms facilitating improved efficacy of adoptive T cell therapy in the liver

Research areas: Immunology, Hepatology

Principal investigator:
Prof. Dr. med. Knolle, Percy
Institute of Molecular Immunology
Technische Universität München
University Hospital Klinikum rechts der Isar
Ismaninger Straße 22
81675 München
Phone: +49 (0)89 4140 6920
Fax: +49 (0)89 4140 6922
E-mail: percy.knolle@tum.de
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General information about Project Z01

Title: Core facility for the construction and characterization of T cell receptor gene-modified T lymphocytes

Research areas: Tumor Immunology, Gene Therapy

Principal investigators:
Prof. Dr. rer. nat. Uckert, Wolfgang
Institute of Biology
Humboldt University Berlin
Max-Delbrück Center for Molecular Medicine
Robert-Rössle- Straße 10, 13092 Berlin
Phone: +49 (0)30 9406 3196
E-Mail: wuckert@mdc-berlin.de

Dr. rer. nat. Frankenberger, Bernhard
Institute of Molecular Immunology
Helmholtz Center Munich
Helmholtz Center Munich - German Research Center for Environmental Health
Marchioinistraße 25, 81377 Munich
Phone: +49 (0)89 3187 1344
E-Mail: b.frankenberger@helmholtz-muenchen.de
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General information about Project Z03

Title: Platform for clinical application of TCR- and CAR-engineered T cells with defined specificity

Research areas: Immunology, Hematology and Oncology

Principal investigators:
Prof. Dr. med. Uharek, Lutz
Department of Hematology and Oncology, Charité Stem Cell Facility
Charité - Universitätsmedizin Berlin
Augustenburgerplatz 1, 13353 Berlin
Phone: +49 (0)30 450 565 151
E-Mail: lutz.uharek@charite.de

Prof. Dr. med. Hildebrandt, Martin
TUMCells Interdisciplinary Center for Cellular Therapies
Faculty of Medicine of the Technical University Munich
Ismaninger Straße 22, 81675 Munich
Phone: +49 (0)89 4140 7810
E-Mail: martin.hildebrandt@lrz.tum.de
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General information about Project V01

Title: Administration of the SFB TR36 and coordination of activities

Spokesperson:
Prof. Dr. rer. nat. Blankenstein, Thomas
Institute of Immunology
Charité Campus Buch
Lindenberger Weg 80, 13125 Berlin
Phone: +49 (0)30 9406 2310
Fax: +49 (0)30 9406 2453
E-Mail tblanke@mdc-berlin.de

SFB Office Berlin:
Erika v. Bühler
Institute of Immunology
Charité Campus Berlin-Buch
Robert-Rössle-Straße 10
13029 Berlin
Phone: +49 30 9406 3307
Fax: +49 30 9406 3306
E-Mail Erika.vonbuehler@mdc-berlin

Deputies Spokespersons:
Prof. Dr. Dirk Busch
Institute for Medical Microbiology, Immunology and Hygiene
Technical University of Munich
Trogerstraße 30
81675 München
Phone: +49 89 4140 4120
Fax: +49 89 4140 4868
E-Mail dirk.busch@tum.de

Prof. Dr. Wolfgang Uckert
Institute of Biology
Humboldt University Berlin
Robert-Rössle-Straße 10
13029 Berlin
Phone: +49 30 9406 3196
Fax: +49 30 9406 3306
E-Mail wuckert@mdc-berlin.de

SFB Office Munich:
Andrea Schulte-Krauss
Institute for Medical Microbiology, Immunology and Hygiene
Technical University of Munich
Trogerstraße 30
81675 München
Phone: +49 89 4140 6840
Fax: +49 89 4140 4868
E-Mail andrea.schultekrauss@tum.de
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SFB TR36 - Charité-Universitätsmedizin Berlin
Prof. Dr. Thomas Blankenstein
Institute of Immunology
Lindenberger Weg 80
13125 Berlin

SFB TR36 -Technische Universität München
Prof. Dr. Dirk Busch
Institute for Medical Microbiology, Immunology and Hygiene
Trogerstraße 30
81675 München