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SYMPOSIUM 2016

Publications sorted by year and author

2016

Bethune MT, Gee MH, Bunse M, Lee MS, Gschweng EH, Pagadala MS, Zhou J, Cheng D, Heath JR, Kohn DB, Kuhns MS, Uckert W, Baltimore D. 2016. Domain-swapped T cell receptors improve the safety of TCR gene therapy. eLife 5:e19095. PMID: 27823582

Bücklein V, Adunka T, Mendler AN, Issels R, Subklewe M, Schmollinger JC, Noessner E. 2016. Progressive natural killer cell dysfunction associated with alterations in subset proportions and receptor expression in soft-tissue sarcoma patients. Oncoimmuno. 5:e1178421. PMID: 27622032

Blankenstein T. 2016. Receptor combinations hone T cell therapy. Nat Biotech. 34:389-391. PMID: 27054992

Buchholz VR, Schumacher TN, Busch DH. 2016. T cell fate at the single-cell level. Annu Rev Immunol. 34:65-92. PMID: 26666651

Deiser K, Stoycheva D, Bank U, Blankenstein T, Schüler T. 2016. Interleukin-7 modulates and anti-tumor CD8T cell responses via its action on host cells. PLos One. 11:e0159690. PMID: 27447484

Durlanik S, Loyal L, Stark R, Sercan Alp Ö, Hartung A, Radbruch A, von Herrath M, Matzmohr N, Frentsch M, Thiel A. 2016. CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice. Eur J Immunol. 46:2566-2573. PMID: 27562840

Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, van den Eynde BJ, Schuler-Thurner B, Schadendorf D, Lorenz FKM, Uckert W, Urban S, Lehmann A, Albrecht-Koepke N, Janek K, Henklein P, Niewienda A, Kloetzel PM, Mishto M. 2016. Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes. Scientific Report. 6:24032. doi:10.1038/srep24032. PMID: 27049119

Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z. 2016. Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4+ T cells. Mol Ther. 24:592-606. PMID: 26755332

Jäckel C, Nogueira MS, Ehni N, Kraus C, Ranke J, Dohmann M, Noessner E, Nelson PJ. 2016. A vector platform for the rapid and efficient engineering of stable complex transgenes. Sci Rep. 6:34365. PMID: 27694838

Japp AS, Hoffmann K, Schlickeiser S, Glauben R, Nikolaou C, Maecker HT, Braun J, Matzmohr N, Sawitzki B, Siegmund B, Radbruch A, Volk HD, Frentsch M, Kunkel D, Thiel A. 2016. Wild immunology assesssed by multidimensional mass cytometry. Cytometry A. doi: 10.1002/cyto.a.22906. PMID: 27403624

Kieback E., Hilgenberg E, Stervbo U, Lampropoulou V, Shen P, Bunse M, Jaimes Y, Boudinot P, Radbruch A, Klemm U, Kühl AA, Liblau R, Hoevelmeyer N, Anderton SM, Uckert W, Fillatreau S. 2016.Thymus-derived regulatory T cells are positevely selected on natural self-antigen through cognate interactions of high functional avidity. Immunity. 44:114-26. PMID: 27192577

Ku MC, Edes I, Bendix I, Pohlmann A, Waiczies H, Prozorovski T, Günter M, Martin C, Pagès G, Wolf SA, Kettenmann H, Uckert W, Niendorf T, Waiczies S. 2016. ERK1 as therapeutic target for dendritic cell vaccination against high grade gliomas. Mol Cancer Ther. 15:1975-1987. PMID: 27256374

Leisegang M, Engels K, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H. 2016. Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation. Clin Cancer Res. 22:2734-2743. PMID: 26667491

Leisegang M, Kammertoens Th, Uckert W, Blankenstein Th. 2016. Targeting human melanoma neoantigens by T cell receptor gene therapy. J Clin Invest. 126:854-8. PMID: 26808500

Lucifora J, Protzer U. 2016. Attacking hepatitis B virus cccDNA - The holy grail to hepatitis B cure. J Hepato. 64:S41-48. PMID: 27084036

Mensali N, Ying F, Oei Yi Sheng V, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J. 2016. Targeting B cell neoplasia with T cell receptors recognizing a CD20-derived peptide on patient-specific HLA. Oncoimm. 5:e1138199. PMID: 27467957

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Erhardt A, Papayannopoulou T, Lieber A. 2016. In vivo transduction of primitive hematopoitic stem cells after monilization and intravenous injection of integrating adenovirus vectors. Blood. 128:2206-2217. PMID: 27554082

Schirmer D, Grünewald TGP, Klar R, Schmidt O, Wohlleber D, Rubio RA, Uckert W Thiel U, Bohne F, Busch DH, Krackhardt A, Burdach S, Richter GH. 2016. Transgenic antigen-specific, allogeneic HLA-A*02:01-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity. Oncoimm. 5:e1175795. PMID: 27471654

Textor A, Schmidt K, Kloetzel P, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher T, Keller C, Busch DH, Seifert U, Blankenstein T. 2016. Preventing tumor escape by targeting a post-proteasomal trimming-independent epitope. J Exp Med. 213:2333-2348. PMID: 27697836

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chao WM, Wettengel J, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Thasler WE, Heikenwaelder M, Protzer U. 2016. Interferon-γ and Tumor Necrosis Factor- αproduced by T cells reduce the HBV persistence form, cccDNA, without cytolysis. Gastro. 150:194-202. PMID: 26416327

 

2015

Bauer C, Hees C, Sterzik A, Bauernfeind F, Mak'Anyengo R, Duewell P, Lehr HA, Noessner E, Wank R, Trauzold A, Endres S, Dauer M, Schnurr M. 2015. Proapoptotic and antiapoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells toward gemcitabine and T cell mediated cytotoxicity. J Immunother. 38:116-26. PMID: 25751501

Blankenstein T, Leisegang M, Uckert W, Schreiber H. 2015. Targeting cancer-specific mutations by T-cell receptor gene therapy. Curr Opin Immunol. 33C:112-119. 10.1016/j.coi.2015.02.005.

Braun J, Frentsch M, Thiel A. 2015. Hobit and human effector T cell differentiation: The beginning of a long journey. Eur J Immunol. 45:2762-5. PMID: 26440905

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U. 2015. T cells engineered to express a T cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice. Gastroenterology. 149: 1042-52. PMID: 26052074.

Durlanik S, Thiel A. 2015. Requirement of immune system heterogeneity for protective immunity. Vacc. 33:5308-12. PMID: 26073012

Ghorashian S, Velica P, Chua I, McNicol AM, Carpenter B, Holler A, Nicholson E, Ahmadi M, Zech M, Xue SA, Uckert W, Morris E, Chakraverty R, Stauss HJ. 2015. CD8 T-cell tolerance to a tumor-associated self-antigen is reversed by CD4 T-cells engineered to express the same T-cell receptor. J Immunol. 194:1080-9. PMID: 25539815.

Grau SJ, Trillsch F, Tonn JC, Goldbrunner RH, Noessner E, Nelson PJ, von Luettichau I. 2015. Podoplanin increases migration and angiogenesis in malignant glioma. Int J Clin Exp Pathol. 8:663-70. PMID: 26339454

Japp AS, Kursunel MA, Meier S, Mälzer JN, Li X, Rahman NA, Jekabsons W, Krause H, Magheli A, Klopf C, Thiel A, Frentsch M. 2015. Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression. Cancer Immunol Immunother. 64:1487-94. PMID: 26289091

Leisegang M, Engels B, Schreiber K, Yew Poh Y, Kiyotani K, Idel Ch, Arina A, Duraiswamy J, Weichselbaum R, Uckert W, Schreiber H. 2015. Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation. doi: 10.1158/1078-0432.CCR-15-2361

Lorenz FK, Wilde S, Voigt K, Kieback E, Mosetter B, Schendel DJ, Uckert W. 2015. Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitpe not harbored by wild-type E7. PLos One. 10(3):e0121633. PMID: 25799237

Obenaus M, Leitao C, Leisegang M, Chen X, Gavvovidis I, van der Bruggen, Uckert W, Schendel DJ, Blankenstein T. 2015. Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice. Nat Biotechnol. 10.1038/nbt.3147.

Rancan C, Schirrmann L, Hüls C, Zeidler R, Moosmann A. 2015. Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells. Pathog. 11(6):e1004906. doi: 10.1371/journal.ppat. PMID: 26067064

Sautto GA, Wisskirchen K, Clementi N, Castelli M, Diotti RA, Graf J, Clementi M, Burioni R, Protzer U, Mancini N. 2015. Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein. Gut. 65:512-23. PMID: 25661083

Schmück-Henneresse M, Sharaf R, Vogt K, Weist BJ, Landwehr-Kenzel S, Fuehrer H, Jurisch A, Babel N, Rooney CM, Reinke P, Volk HD. 2015. Peripheral blood-derived virus-specific memory stem T cells mature to functional effector memory subsets with self-renewal potency. J Immunol. 194:5559-67. PMID: 25917088.

Sercan Alp Ö, Durlanik S, Schulz D, McGrath M, Grün JR, Bardua M, Ikuta K, Sgouroudis E, Riedel R, Zehentmeier S, Hauser AE, Tsuneto M, Melchers F, Tokoyoda K, Chang HD, Thiel A, Radbruch A. 2015. Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription. Eur J Immunol. 45:975-87. PMID: 25639669

Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. 2015. Immunosuppressive plasma cells impede T -cell-dependent immunogenic chemotherapy. Nat. 521:94-8. PMID: 25924065

Stoycheva D, Deiser K, Stärck L, Nishanth G, Schlüter D, Uckert W, Schüler T. 2015. IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals. J Immunol. 194:553-9. PMID: 25480562.

Toma M, Wehner R, Kloß A, Hübner L, Fodelianaki G, Erdmann K, Füssel S, Zastrow S, Meinhardt M, Seliger B, Brech D, Noessner E, Tonn T, Schäkel K, Bornhäuser M, Bachmann MP, Wirth MP, Baretton G, Schmitz M. 2015. Accumulation of tolerogenic human 6-sulfo LacNAc dendritic cells in renal cell carcinoma is associated with poor prognosis. Oncolimmuno. 4:e1008342. PMID: 26155414

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Götz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J. 2015. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest. 125:699-714. doi: 10.1172/JCI76210. PMID: 25607842

 

2014

Ameres S, Besold K, Plachter B, Moosmann A. 2014. CD8 T cell-evasive functions of human cytomegalovirus display pervasive MHC allele specificity, complementarity, and cooperativity. J Immunol. 192(12):5894-905. doi: 10.4049/jimmunol.1302281. PMID:24808364.

Bretschneider I, Clemente MJ, Meisel C, Guerreiro M, Streitz M, Hopfenmüller W, Maciejewski JP, Wlodarski MW, Volk HD. 2014. Discrimination of T cell subsets and T cell receptor repertoire distribution. Immunol Res. 58(1):20-7. Doi:10.1007/s12026-013-8473-0.

Bunse M, Bendle GM, Linnemann C, Bies L, Schulz S, Schumacher TN, Uckert W. 2014. RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer. Mol Ther22(11):1983-1991 PMID:25048215

 

Gomez-Eerland R, Nuijen B, Heemskerk B, van Rooij N, van den Berg JH, Beijnen JH, Uckert W, Kvistborg P, Schumacher T, Haanen JB, Jorritsma A. 2014. Manufacture of gene-modified human T cells with a memory stem/central memory phenotype. Hum Gene Ther Methods. 25:277-287.

 

Graef P, Buchholz VR, Stemberger C, Flossdorf M, Henkel L, Schiemann M, Drexler I, Hofer T, Riddell SR, Busch DH. 2014. Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. Immunity. 41:116-26. PMID:25035956
 
Lehmann FM, Maurberger A, Feicht S, Helm F, Ladinig C, Kieback E, Uckert W, Kammertöns T, Kremmer E, Mautner J, Gerbitz A, Bornkamm GW. 2014. Targeting high-grade B cell lymphoma with CD19-specific T cells. Int J Cancer 135:1153-1164. PMID:2500882
 
Loebel M, Strohschein K, Giannini C, Koelsch U, Bauer S, Doebis C, Thomas S, Unterwalder N, von Baehr V, Reinke P, Knops M, Hanitsch LG, Meisel C, Volk HD, Scheibenbogen C. 2014. Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome. PLoS One. 9(1):e85387.doi:10.1371/journal.pone.0085387. PMID:24454857
 
Odendahl M, Grigoleit G, Bonig H, Neuenhahn M, Albrecht J, Anderl F, Germeroth L, Schmitz M, Bornhauser M, Einsele H, Seifried E, Busch DH, Tonn T. 2014. Clinical-scale isolation of 'minimally manipulated' cytomegalovirus-specific donor lymphocytes for treatment of refractory cytomegalovirus disease. Cythotherapy. 16:1245-56. PMID:25108651
 
Perez C, Jukica A, Listopad JJ, Anders K, Kühl AA, Loddenkemper C, Blankenstein T, Charo J. 2014. Permissive expansion and homing of adoptively transferred T-cells in tumor-bearing hosts. Int J Cancer. doi: 10.1002/ijc.29401. PMID: 25530110.
 
Pinto S, Sommermeyer D, Michel C, Wilde S, Schendel DJ, Uckert W, Blankenstein T, Kyewski B. 2014. Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T-cells. Eur J Immunol. 44:2811-2821. PMID: 24114521
 
Reuß S, Sebestyén Z, Heinz N, Loew R, Baum C, Debets R, Uckert W. 2014. TCR-engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs. Eur J Immunol. 44:265-274. PMID:24114521
 
Schendel DJ and Greenberg PD.  2014. The ABCs of T Cell Receptor Gene Therapy. Cancer Immuntherapy Meets Oncology. Springer International Publishing, Switzerland, p.117-126. DOI 10.1007/978-3-319-05104-8

 

Steger B, Milosevic S, Doessinger G, Reuther S, Liepert A, Braeu M, Schick J, Vogt V, Schuster F, Kroell T, Busch DH, Borkhardt A, Kolb HJ, Tischer J, Buhmann R, Schmetzer H. 2014. CD4(+) and CD8(+) T cell reactions against leukemia-associated- or minor-histocompatibility-antigens in AML-patients after allogeneic SCT. Immunobiol. 219:247-60. DOI:10.1016/j.imbio.2013.10.008. PMID: 24315637
 
Stemberger C, Schiemann M, Grigoleit GU, Schuster FR, Borkhardt A, Versluys B, Tonn T, Seifried E, Einsele H, Germeroth L, Busch DH, Neuenhahn M. 2014. Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy. Blood. 124:628-37. PMID: 24855206
 
Stärck L, Mueller K, Pircher H, Uckert W. 2014. Immunotherapy with TCR-redirected T cells: Comparison of TCR-transduced and TCR-engineered HSC-derived T cells. J Immunol. 192:206-213.
 
Textor A, Listopad JJ, Wührmann LL, Perez C, Kruschinski A, Chmielewski M, Abken H, Blankenstein T, Charo J. 2014. Cancer Res. Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNy. Cancer Res. 74:6796-805

 

 

2013

 

Abou-El-Enein M, Roemhild A, Kaiser D, Beier C, Bauer G, Volk HDReinke P. 2013. Good Manufacturing Practices (GMP) manufacturing of advanced therapy medicinal products: a novel tailored model for optimizing performance and estimating costs. Cytotherapy. 15(3):362-83.
 
Ameres S, Mautner J, Schlott F, Neuenhahn M, Busch DH, Plachter B and Moosmann A. 2013. Presentation of an immunodominant immediate-early CD8+ T cell epitope resists human cytomegalovirus immunoevasion. PLoS Pathog 9:e1003383.
 
Anders K and Blankenstein Th. 2013. Comparing the effects of drugs and T cells to effectively target oncogenes. Clin Cancer Res. 19:320-326.

Bottcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Hochst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath M F, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA. 2013. Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Rep. 3:779-795.

Buchholz VR, Graf P, Busch DH. 2013. The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level. Front Immunol. 4:31.

Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Graf P, Verschoor A, Schiemann M, Hofer T, Busch DH. 2013. Disparate individual fates compose robust CD8+ T cell immunity. Science. 340:630-635.

Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M. 2013. Inflammatory chemokines and metastasis – tracing the accessory. Oncogene. doi: 10.1038/onc.2013.272.
 
Bäuerlein CA, Riedel S, Baker J, Brede C, Garrote ALJ, Chopra M, Ritz M, Beilhack GF, Schulz S, Zeiser R, Schlegel PG, Einsele H, Negrin RS, Beilhack A. 2013. A diagnostic window for the treatment of acute GVHD prior to visible clinical symptoms in a murine model. BMC Med. 11:134.

Christopeit M, Kuss O, Finke J, Bacher U, Beelen DW, Bornhäuser M, Schwerdtfeger R, Bethge WA, Basara N, Gramatzki M, Tischer J, Kolb HJ, Uharek L, Meyer RG, Bunjes D, Scheid C, Martin H, Niederwieser D, Kröger N, Bertz H, Schrezenmeier H & Schmid C. 2013. Second allograft for hematologic relapse of acute leukemia after first allogeneic stem-cell transplantation from related and unrelated donors: the role of donor change. J Clin Onco. 31:3259–3271.

Djafarzadeh R, Notohamiprodjo S, Rieth N, Hofstetter M, Noessner E, Nelson PJ. 2013. Treatment of Dermal Fibroblasts with GPI-Anchored Human TIMP-1 Protein Moderates Processes Linked to Scar Formation. J Invest Dermatol. 133(3):803-11.

Dossinger G, Bunse M, Bet J, Albrecht J, Paszkiewicz PJ, Weissbrich B, Schiedewitz I, Henkel L, Schiemann M, Neuenhahn M, Uckert W and Busch DH. 2013. MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy. PLoS One. 8:1-11.

Dreger P, Schnaiter A, Zenz T, Böttcher S, Rossi M, Paschka P, Buhler A, Dietrich S, Busch R, Ritgen M, Bunjes D, Zeis M, Stadler M, Uharek L, Scheid C, Hegenbart U, Hallek M, Kneba M, Schmitz N, Döhner H & Stilgenbauer S. 2013. TP53, SF3B1, and NOTCH1 mutations and outcome of allotransplantation for chronic lymphocytic leukemia: six-year follow-up of the GCLLSG CLL3X trial. Blood. 121:3284–3288.

Dziubianau M, Hecht J, Kuchenbecker L, Sattler A, Stervbo U, Neumann AU, Robinson PN, Mundlos S, Volk HD, Thiel A, Reinke P, Babel N. 2013. TCR repertoire analysis by next generation sequencing allows complex differential diagnosis of T-cell related pathology. Am J Transplant. 13:2842-2854.

Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E. 2013. Immunoproteasomes are important for proteostasis in immune responses. Cell. 152:935-937.

Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz AR, Stervbo U, Jürchott K, Gebhardt F, Heine G, Reuter MA, Betts MR, Busch D, Thiel A. 2013. CD40L expression permits CD8+ T cells to execute immunological helper functions. Blood. 122:405-412.

Hanazawa A. Lohning M, Radbruch A, Tokoyoda K. 2013. CD49b/CD69-Dependent Generation of Resting T Helper Cell Memory. Front Immunol. 4:183-187.

Hammoud B, Schmueck M, Fischer AM, Fuehrer H, Park SJ, Akyuez L, Schefold JC, Raftery MJ, Schönrich G, Kaufmann AM, Volk HD, Reinke P. 2013. HCMV-specific T-cell therapy: do not forget supply of help.  J Immunother. 36(2):93-101.

Helm F, Kammertoens T, Lehmann FM, Wilke A, Bruns H, Mautner J, Bornkamm GW, Gerbitz A. 2013. Targeting c-MYC with T-Cells. PLoS One. 8(10):e77375.

Hess Michelini R, Manzo T, Sturmheit T, Basso V, Rocchi M, Freschi M, Listopad J, Blankenstein Th, Bellone M and Mondino A. 2013. Vaccine-instructed intratumoral IFN- enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation. Cancer Res. 73:4641-4652.
 
Hombrink P, Raz Y, Kester MG, de Boer R, Weissbrich B, von dem Borne PA, Busch DH, Schumacher TN, Falkenburg JH, and Heemskerk MH. 2013. 
Mixed functional characteristics correlating with TCR-ligand k -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire. Eur J Immunol. 43(11):3038-50.
 
Huang LR, Wohlleber DP, Reisinger F, Kurts C, Protzer U, Heikenwalder M, Knolle PA. 2013. Intrahepatic myeloid cell-aggregates enable local CD8+ T cell expansion and successful immunotherapy against chronic viral liver infection. Nat Immunol. 6:574-83. doi: 10.1038/ni.2573. Epub 2013 Apr 14
 
Kammertoens T and Blankenstein Th. 2013. It’s the peptide-MHC affinity, stupid. Cancer Cell. 23:429-431.
 
Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U. 2013. T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelop Proteins Control Virus Replication in MiceGastroenterology. 145(2):456-65.
 
Kudernatsch RF, Letsch A, Stachelscheid H, Volk HD, Scheibenbogen C. 2013. Doublets pretending to be CD34+ T cells despite doublet exclusion. Cytometry. 83(2):173-6.

Li LP and Blankenstein Th. 2013. Generation of transgenic mice with megabase-sized human yeast artificial chromosomes by yeast spheroplast-embryonic stem cell fusion. Nat Protoc. 8:1567-1582.

Linnemann C, Heemskerk B, Kvistborg P, Kluin R, Bolotin D, Chen X, Bresser K, Nieuwland M, Schotte R, Michels M, Gomez-Eerland R, Jahn L, Hombrink P, Legrand N, Jenny Shu C, Mamedov I, Velds A, Blank C, Haanen J, Turchaninova M, Kerkhoven R, Spits H, Reker-Hadrup S, Heemskerk M, Blankenstein Th, Chudakov D, Bendle G, Schumacher T. 2013. High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med. 19:1534-1541.

Listopad JJ, Kammertöns T, Anders K, Silkenstedt B, Willimsky G, Schmidt K, Kühl A, Loddenkemper C, Blankenstein Th. 2013.
Fas expression by tumor stroma is required for cancer eradication. Proc Natl Acad Sci USA. 110:2276-2281.

Mensen A, Ochs C, Stroux A, Wittenbecher F, Szyska M, Imberti L, Fillatreau S, Uharek L, Arnold R, Dörken B, Thiel A, Scheibenbogen C & Na I-K. 2013. Utilization of TREC and KREC quantification for the monitoring of early T- and B-cell neogenesis in adult patients after allogeneic hematopoietic stem cell transplantation. J Transl Med. 11:188.

Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Muenchmeier N, Boecker S, Bankel L, Hinz L, Rieth N, Lapa C, Mendler AN, Noessner E, Mocikat R*, Nelson PJ*. 2013. A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy. Plos One. 8(8):e72749.

Mueller-Loebnitz C, Ostermann H, Franzke A, Loeffler J, Uharek L, Topp M & Einsele H. 2013. Immunological aspects of Candida and Aspergillus systemic fungal infections. Interdiscip Perspect Infect Dis. 102934–7.

Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA. 2013. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother. 36(2):133-151.

Nauerth M, Weissbrich B, Busch DH. 2013. The clinical potential for koff-rate measurement in adoptive immunotherapy. Expert Rev Clin Immunol. 9:1151-1153.

Nauerth M, Weissbrich B, Knall R, Franz T, Dossinger G, Bet J, Paszkiewicz PJ, Pfeifer L, Bunse M, Uckert W, Holtappels R, Gillert-Marien D, Neuenhahn M, Krackhardt A, Reddehase MJ, Riddell SR and Busch DH. 2013. TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer. Sci Transl Med. 5:192ra87.

Neuenhahn M, Busch DH. 2013. Whole-body anatomy of human T cells. Immunity. 38:10-12.

Pohla H, Buchner A, Stadlbauer B, Frankenberger B, Stevanovic S, Walter S, Frank R, Schwachula T, Olek S, Kopp J, Willimsky G, Stief C, Hofstetter A, Pezzutto A, Blankenstein Th, Oberneder R and Schendel DJ. 2013. High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination. Mol Med. 18:1499-1508.

Reuss S, Sebestyen Z, Heinz N, Loew R, Baum C, Debets R and Uckert W. 2013. TCR-engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs. Eur J Immunol.

Rothe M, Quarcoo D, Chashchina A, Bozrova S, McKenzie A, Qin Z, Nedospasov S, Blankenstein Th, Kammertöns K and Drutskaya M. 2013. IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis. Cancer Med. 2:815-825.

Schendel DJ, Frankenberger B. 2013. Limitations for TCR gene therapy by MHC-restricted fratricide and TCR-mediated hematopoietic stem cell toxicity. Oncoimmunology. 2(1):e22410

Schmidt K, Zilio S, Schmollinger JC, Bronte V, Blankenstein Th, Willimsky G. 2013. Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer. Blood. 121:1740-1748.

Schroeder T, Czibere A, Platzbecker U, Bug G, Uharek L, Luft T, Giagounidis A, Zohren F, Bruns I, Wolschke C, Rieger K, Fenk R, Germing U, Haas R, Kröger N & Kobbe G. 2013. Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation. Leukemia. 27:1229–1235.

Schroeder T, Fröbel J, Cadeddu R-P, Czibere A, Dienst A, Platzbecker U, Bug G, Uharek L, Fenk R, Germing U, Kröger N, Haas R & Kobbe G. 2013. Salvage therapy with azacitidine increases regulatory T cells in peripheral blood of patients with AML or MDS and early relapse after allogeneic blood stem cell transplantation. Leukemia. 27:1910–1913.

Smith SN, Sommermeyer D, Piepenbrink KH, Blevins SJ, Bernhard H, Uckert W, Baker BM and Kranz DM. 2013. Plasticity in the Contribution of T Cell Receptor Variable Region Residues to Binding of Peptide-HLA-A2 Complexes. J Mol Biol. 425:4496-507.

Sommermeyer D, Conrad H, Krönig H, Gelfort H, Bernhard H, Uckert W. NY-ESO-1 antigen-reactive T cell receptors exhibit diverse therapeutic capability. 2013. Int J Cancer.132:1360-7 PMID: 22907642

Stark R, Hartung A, Zehn D, Frentsch M, Thiel A. 2013. IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8(+) T cells. Eur J Immunol. 43:1507-1511.

Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwaelder M, Luedde T. 2013. RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation. Cell Rep. doi:pii: S2211-1247(13)00397-5.10.1016.
 
Willimsky G, Schmidt K, Loddenkemper C, Gellermann J, Blankenstein T. 2013Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123:1032-1043.

Willimsky G, Protzer U, Knolle PA and Heikenwälder M. 2013. Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key? Oncotarget. 4:1117-1118.

Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein Th. and Qin Z. 2013.
Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res. 73: 2770-2781.

 

2012

Anders K, Buschow C, Charo J, Blankenstein Th. 2012. Depot formation of doxycycline impairs Tet-regulated gene expression in vivo. Transgenic Res. 21:1099-1107.

Blankenstein Th, Coulie PG, Gilboa E, Jaffee EM. Viewpont: The determinants of tumour immunogenicity. Nat Rev Cancer.12: 307-313.

Brede C, Friedrich M, Jordan-Garrote AL, Riedel S-S, Bäuerlein CA, Heinze KG, Bopp T, Schulz S, Mottok A, Kiesel C, Mattenheimer K, Ritz M, von Krosigk V, Rosenwald A, Einsele H, Negrin RS, Harms GS, Beilhack A. Mapping immune processes in intact tissues at cellular resolution. J Clin Invest. 2012. 122:4439-46.

Briesemeister D, Friese C, Cuartero-Isern C, Dietz E, Blankenstein Th, Thoene-Reineke C, Kammertöns T. 2012. Differences in serum cytokine levels between wild type mice and mice with a targeted mutation suggests necessity of using control littermates. Cytokine. 60:626-633.

Buchholz VR, Graf P, Busch DH. 2012. The origin of diversity: studying the evolution of multi-faceted CD8+ T cell responses. Cell Mol Life Sci. 69:1585-1595.

Burmeister T, Molkentin M, Meyer C, Lachmann N, Schwartz S, Friedrichs B, Beyer J, Blau IW, Lohm G, Tietze-Bürger C, Marschalek R & Uharek L. 2012. Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse. Exp Hematol Oncol.1:6.

Casper J, Holowiecki J, Trenschel R, Wandt H, Schaefer-Eckart K, Ruutu T, Volin L, Einsele H, Stuhler G, Uharek L, Blau I, Bornhaeuser M, Zander AR, Larsson K, Markiewicz M, Giebel S, Kruzel T, Mylius HA, Baumgart J, Pichlmeier U, Freund M & Beelen DW. 2012. Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning. Bone Marrow Transplant. 47(9):1171-7
 
Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP. 2012.
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.
Gut. 61:427-38. doi: 10.1136/gutjnl-2011-300509. 

Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland N, Jenkins N, Weber A, Kiat Hon Lim K, Toh HC, Heikenwalder M, Ng I, Nardin A, Abastado JP.TLR3-expressing Tumor Parenchyma and Infiltrating NK Cells Promote Tumor Control in Hepatocellular Carcinoma Patients. 2012J Natl Cancer Inst. 104:1796-807. doi: 10.1093/jnci/djs436. Epub 2012 Nov 29.

Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wörnle M, Ribeiro A, Himmelein S, Sitter T, Nelson PJ. Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. 2012. PLoS One. 7(4):e33963.

Ebstein F, Kloetzel PM, Krüger E, Seifert U. 2012. Emerging roles of immunoproteasomes beyond MHC class I antigen processing. Cell Mol Life Sci. DOI 10.1007/s00018-012-0938-0.

Eckl J, Buchner A, Prinz UP, Riesenberg R, Kammerer R, Siegert SI, Nelson PJ, Noessner E. 2012. Tissue transcript signature allows prediction of NK cells in renal cell carcinoma tissue independent of TNM staging. J Mol Med. 90(1):55-66.

Frankenberger B, Schendel D.J. Third generation dendritic cell vaccines for tumor immunotherapy. Eur J Cell Biol. 2012. 91(1):53-8.

Frenzel K, Ganepola S, Michel D, Thiel E, Krüger DH, Uharek L & Hofmann J. 2012. Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell lines. Med Microbiol Immunol.

Fuhrmann S, Lachmann R, Streitz M, Hetzer R, Volk HD, Lehmkuhl H, Kern F. Cyclosporin A and tacrolimus reduce T-cell polyfunctionality but not interferon-γ responses directed at cytomegalovirus. 2012. Immunology. 136(4):408-13.

Gerbitz A, Sukumar M, Helm F, Wilke A, Friese C, Fahrenwaldt C, Lehmann F, Loddenkemper C, Kammertöns T, Mautner J, Schmitt C, Blankenstein Th, Bornkamm G. 2012. Stromal interferon-Y signaling and cross-presentation are required to eliminate antigen-loss vriants of B cell lymphomas in mice. PLoS ONE. 7:e34552.

Herda S, Mittrücker HW, Raczkowski F, Willimsky G, Gerlach K, Kühl A, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A. 2012. Sortilin exhibits a dual function for exocytic trafficking  of effector cytokines and granzymes in T cells. Immunity. 37:854-866.

Hilgendorf I, Wolff D, Nogai A, Kundt G, Hahn J, Holler E, Uharek L, Junghanss C, Leithäuser M, Thiel E, Freund M & Kahl C. 2012. Chronic graft versus host disease but not the intensity of conditioning has impact on survival after allogeneic hematopoietic stem cell transplantation for advanced hematological diseases. Onkologie. 35:487–492.

Hoos A, Wolf MJ, Bauer J, Borsig L, Heikenwalder M. 2012. Endothelial chemokine receptors as facilitators of tumor cell extravasation? Oncotarget. 3:919-20.
 
Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U. Transfer of HBV Genomes Using Low Doses of Adenovirus Vectors Leads to Persistent Infection in Immune Competent Mice. 2012. Gastroenterology. 142:1447-50.e3. doi: 10.1053/j.gastro.2012.03.006. 

Jochum S, Moosmann A, Lang S, Hammerschmidt W, Zeidler R. 2012. The EBV immunoevasins vIL-10 and BNLF2a protect newly infected B cells from immune recognition and elimination. PLoS Pathog. 8: e1002704.

Jochum S, Ruiss R, Moosmann A, Hammerschmidt W, Zeidler R. 2012. RNAs in Epstein-Barr virions control early steps of infection. Proc Natl Acad Sci U S A. 109:E1396-404.

Kalla M, Göbel C, Hammerschmidt W. 2012. The lytic phase of Epstein-Barr virus requires a viral genome with 5-methylcytosine residues in CpG sites. J Virol. 86:447-58.

Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein Th. 2012. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT - cells and their effector molecules ( Fas-ligand, TNF-α, perforin) Int J Cancer. 131: 1499-1508.

Kohler S, Bethke N, Böthe M, Sommerick S, Frentsch M, Romagnani C, Niedrig M, Thiel A. 2012. The early cellular signatures of protective immunity induced by live viral vaccination. Eur J Immunol. 42(9):2363-73.

Krönig H, Falchner JK, Odendahl M, Brackertz B, Conrad H, Muck D, Hein R, Blank C, Peschel C, Haller B, Schulz S, Bernhard H. 2012. PD-1 expression on Melan-A-reacive T cells increases during progression to metastatic disease. Int J Cancer. 130:2327-36.

Lampropoulou V, Shen P, Hilgenberg E, Ries S, Opitz C, Fillatreau S. 2012. Functional interactions between B lymphocytes and the innate immune system. Infect Disord Drug Targets. 12(3):191-9.

Lichtenegger FS, Mueller K, Otte B, Beck B, Hiddemann W, Schendel DJ, Subklewe M. 2012. CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells. PLoS One. 7(9):e44266. PMID: 22962607

Martin LK, Schub A, Dillinger S, Moosmann A. 2012. Specific CD8(+) T cells recognize human herpesvirus 6B. Eur J Immunol. 42:2901-2912.

Mendler AN*, Hu B*, Prinz PU, Kreutz M, Gottfried E, Noessner E. 2012. Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. Int J Cancer. 131(3):633-40.

Moosmann A, Hammerschmidt W, Kolb HJ. 2012. Virus-specific T cells for therapy–approaches, problems, solutions. Eur J Cell Biol. 91:97-101.

Mueller K, von Mässenhausen A, Aichele U, Stärck L, Leisegang M, Uckert W, Pircher H. 2012. Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo. J Virol. 86(19):10866-9. PMID: 22787223

Na I-K, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, Blau O, Blau IW, Thiel E, Uharek L, Scheibenbogen C, Rieger K & Thiel A. 2012. Rabbit antithymocyte globulin (Thymoglobulin(R)) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica.

Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, Peter von Kries J, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ, Krappmann D. 2012. Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL. Cancer Cell. 11:22(6):825-37. PMID:23238017

Patra AK, Avots A, Zahedi RP, Schüler T, Sickmann A, Bommhardt U and Serfling E. 2012. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol. 14:127-135.

Prinz PU, Mendler AN, Masouris I, Durner L, Oberneder R, Noessner E. 2012. High DGK-α and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention. J Immunol. 188: 5990-6000.

Schendel DJ. 2012. Is it time to abandon RHAMM/HMMR as a candidate antigen for immunotherapy of acute myeloid leukemia? Haematologica.1:1(9):1643-1644. PMID: 23264922

Schendel DJ, Wilde S, Leisegang M, Uckert W. 2012. Response to Comment on Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition. J Immunol.189:3787-3788.

Scheumann N, Kieback E, Uckert W. 2012. Safety modality for X-linked severe combined immunodeficiency gene therapy. J Cell Sci. Ther. doi.org/10.4172/2157-7013.1000121.

Schmueck M, Fischer AM, Hammoud B, Brestrich G, Fuehrer H, Luu SH, Mueller K, Babel N, Volk HD, Reinke P. 2012. Preferential expansion of human virus-specific multifunctional central memory T cells by targeting of the IL-2 receptor signaling pathway: the key role of CD4+ T cells. J Immunology. 15:188(10):5189-98.

Schoenbrunn A, Frentsch M, Kohler S, Keye J, Dooms H, Moewes B, Dong J, Loddenkemper C, Sieper J, Wu P, Romagnani C, Matzmohr N, Thiel A. 2012. A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg ) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg. J Immunology. 15:189(12):5985-94.

Schulze H, Todorova K, Cirocki J, Uharek L & Schönemann C .2012. Detection of a novel HLA-A allele, designated A*02:334. Tissue Antigens 80:191.

Schwele S, Fischer AM, Brestrich G, Wlodarski MW, Wagner L, Schmueck M, Roemhild A, Thomas S, Hammer MH, Babel N, Kurtz A, Maciejewski JP, Reinke P, Volk HD. 2012. Cytomegalovirus-specific regulatory and effector T cells share TCR clonality--possible relation to repetitive CMV infections. Am J Transplant. 12(3):669-81.

Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Stephan Regenass  S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, MacPherson A, Manz M, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M. 2012. Lymphotoxin ß Receptor Signaling Promotes Development of Autoimmune PancreatitisGastroenterology. 143:1361-74. doi: 10.1053/j.gastro.2012.07.112. Epub 2012 Aug 2.

Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan O, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ,  Arnold B, Siegmund B and Schüler T. 2012. Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS One. 7:e31939.

Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A, Nakayama T. 2012. Type II membrane protein CD69 regulates the formation of resting T-helper memory. PNAS 109:7409-7414.

Spranger S, Jeremias I, Wilde S, Leisegang M, Stärck L, Mosetter B, Uckert W, Heemskerk MH, Schendel DJ, Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood.12:119(15):3440-9 PMID: 22371883

Stemberger C, Dreher S, Tschulik C, Piossek C, Bet J, Yamamoto TN, Schiemann M, Neuenhahn M, Martin K, Schlapschy M, Skerra A, Schmidt T, Edinger M, Riddell SR, Germeroth L, Busch DH. 2012. Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS One. 7:e35798.

Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U. 2012. The efficiency of HCMV pp65495-503 CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and ER-resident peptidases. J Immunol. 189(2):529-538.

Wendtner CM, Hillmen P, Mahadevan D, Bühler A, Uharek L, Coutré S, Frankfurt O, Bloor A, Bosch F, Furman RR, Kimby E, Gribben JG, Gobbi M, Dreisbach L, Hurd DD, Sekeres MA, Ferrajoli A, Shah S, Zhang J, Moutouh-de Parseval L, Hallek M, Heerema NA, Stilgenbauer S & Chanan-Khan AA. 2012. Final results of a multicenter phase 1 study of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia. Leuk Lymphoma. 53:417–423.

Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel DJ. 2012. Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells. A three phase experimental procedure. Oncolmmunology. 1:1-13.

Wilde S, Schendel DJ. 2012. High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them. Oncoimmunology. 1:1(9):1643-1644. PMID 23264922

Wilde S, Sommermeyer D, Leisegang M, Frankenberger B, Mosetter B, Uckert W, Schendel DJ. 2012. Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition. J Immunol. 189(2):598-605. Epub 2012 Jun 11. PMID: 22689880

Woellmer A, Arteaga-Salas JM, Hammerschmidt W. 2012. BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression. PLoS Pathog. 8:e1002902.

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA. 2012. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Rep. 2:478-87. doi: 10.1016/j.celrep.2012.08.001. 
 
Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz M, Moch H, Aguzzi A, Van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwaelder M. 2012. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell. 22:91-105. doi: 10.1016/j.ccr.2012.05.023.

Zhou Q, Schneider IC, Edes I, Honegger A, Bach P, Schönfeld K, Schambach A, Wels WS, Kneissl S, Uckert W, Buchholz CJ. 2012. T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing.
Blood. PMID: 22898597

 

2011

Anders K, Buschow C, Herrmann A, Milojkovic A, Loddenkemper C, Kammertoens T, Daniel P, Yu H, Charo J, Blankenstein T. 2011. Oncogene-targeting T Cells targeting reject large tumors while oncogene Inactivation selects escape variants in mouse models of cancer. Cancer Cell.13:20(6):755-67. 

Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J. 2011. Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther. 13(3):R95.

Babel N, Volk HD, Reinke P. 2011. BK polyomavirus infection and nephropathy: the virus-immune system interplay. Nat Rev Nephrol. 7(7):399-06.

Beck B, Dörfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M. 2011. Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission. J Transl Med. 9:151.

Buchholz VR, Neuenhahn M, Busch DH. 2011. CD8(+) T cell differentiation in the aging immune system: until the last clone standing. Curr Opin Immunol. 23:549-554.

Bukur J, Noessner E, Seliger B. 2011. Tumor Immunology meets Oncology (TIMO) VII from the 14th-16th of April 2011 in Halle/Saale, Germany. Cancer Immunol Immunother. 60(11):1647-53.

Butterfield LH, Palucka AK, Britten CM, Dhodapkar MV, Hakansson L, Janetzki S, Kawakami Y, Kleen TO, Lee PP, Maccalli C, Maecker HT, Maino VC, Maino VC, Maio M, Malyguine A, Masucci G, Pawelec G, Potter DM, Rivoltini L, Salazar LG, Schendel DJ, Slingluff CL Jr, Song W, Stroncek DF, Tahara H, Thurin M, Trinchieri G, van der Burg SH, Whiteside TL, Wigginton JM, Marincola F, Khleif S, Fox BA, Disis ML. 2011. Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res. 17(10):3064-76.

Charo J, Perez C, Buschow C, Jukica A, Czeh M, Blankenstein T. 2011. Visualizing the dynamic of adoptively transferred T cells during rejection of large established tumors. Eur J Immunol. 41(11):3187-97.

Figel A-M, Brech D, Prinz UP, Lettenmeyer UK, Eckl J, Turqueti-Neves A, Mysliwietz J, Anz D, Rieth N, Muenchmeier N, Buchner A, Porubsky S, Siegert SI, Segerer S, Nelson PJ, Noessner E. 2011. Human renal cell carcinoma induces a dendritic cell subset that uses T-cell crosstalk for tumor-permissive milieu alterations. Am J Path. 179:436-51.

Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA, Atkins MB, Bartunkova J, Bergmann L, Berinstein N, Bonorino CC, Borden E, Bramson JL, Britten CM, Cao X, Carson WE, Chang AE, Characiejus D, Choudhury AR, Coukos G, de Gruijl T, Dillmann RO, Dolstra H, Dranoff G, Durrant LG, Finke JH, Galon J, Gollob JA, Goutefangeas C, Grizzi F, Guida M, Hakansson L, Hege K, Herberman RB, Hodi FS, Hoos A, Huber C, Hwu P, Imai K, Jaffee EM, Janetzki S, June CH, Kalinski P, Kaufmann HL, Kawakami K, Kawakami Y, Keilholz U, Khleif SN, Kiessling R, Kotlan B, Kroemer G, Lapointe R, Levitsky HI, Lotze MT, Macalli C, Maio M, Marschner JP, Mastrangelo MJ, Masucci G, Melero I, Nelief C, Murphy WJ, Nelson B, Nicolini A, Nishimura MI, Odunsi K, Ohashi PS, O'Donnell-Tormey J, Old LJ, Ottensmeier C, Papamichail M, Parmiani G, Pawelec G, Proietti E, Qin S, Rees R, Ribas A, Ridolfi R, Ritter G, Rivoltini L, Romero PJ, Salem ML, Scheper RJ, Seliger B, Sharma P, Shiku H, Singh-Jasuja H, Song W, Straten PT, Tahara H, Tian Z, van Der Burg SH, von Hoegen P, Wang E, Welters M.J, Winter H, Withington T, Wolchok JD, Xiao W, Zitvogel L, Zwierzina H, Marincola FM, Gajewski TF, Wigginton JM, Disis ML. 2011. Defining the Critical Hurdles in Cancer Immunotherapy. J Transl Med. 9(1):214.

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature. 479:547-51. doi: 10.1038/nature10599

Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, De Ru A, van Montfoort N, Franken KLMC, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis IIN, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJM. 2011. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Nat Immunol. 12(1)45-53 IF 26.218.

Lehrnbecher T, Schmidt S, Koehl U, Schuster FR, Uharek L, Klingebiel T & Tramsen L. 2011. Adoptive antifungal T cell immunotherapy--into the clinic? Med Mycol. 49:164–9.

Lindenmeyer M, Noessner E, Nelson PJ, Segerer S. 2011. Dendritic cells in experimental renal inflammation (part I). Nephron Exp Nephrol 119(4):e83-90.

Mueller K, Schachtner T, Sattler A, Meier S, Friedrich P, Trydzenskaya H, Hinrichs C, Trappe R, Thiel A, Reinke P, Babel N. 2011. BK-VP3 as a new target of cellular immunity in BK virus infection. Transplantation. 91(1):100-7.

Neumann M, Blau IW, Burmeister T, Tietze-Buerger C, Blau O, Gerbitz A, Uharek L & Thiel E. 2011. Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation. Ann Hematol.
90(8):911

Noessner E, Lindenmeyer M, Nelson PJ, Segerer S. 2011. Renal dendritic cells – Part II: Phenotype and function in human renal inflammation. Nephron Exp Nephrol. 119(4):e91-8.

Popovic J, Li L-P, Kloetzel P-M, Leisegang M, Uckert W, Blankenstein Th. 2011. The only proposed T cell epitope derived from the TEL-AML1 translocation is not naturally processed. Blood. 118:946-954 PMID: 21613253

Roider E, Jellbauer S, Kohn B, Berchtold C, Partilla M, Busch DH, Russmann H and Panthel K. 2011. Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer. Cancer Immunol Immunother. 60:371-380.

Ruiss R, Jochum S, Wanner G, Reisbach G, Hammerschmidt W, Zeidler R. 2011. A virus-like particle-based Epstein-Barr virus vaccine. J Virol 85:13105-13113.

Ruutu T, Volin L, Beelen DW, Trenschel R, Finke J, Schnitzler M, Holowiecki J, Giebel S, Markiewicz M, Uharek L, Blau I, Kienast J, Stelljes M, Larsson K, Zander AR, Gramatzki M, Repp R, Einsele H, Stuhler G, Baumgart J, Mylius HA, Pichlmeier U, Freund M & Casper J. 2011. Reduced-toxicity conditioning with treosulfan and fludarabine in allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes: final results of an international prospective phase II trial. Haematologica. 96(9):1344-50.

Schachtner T, Müller K, Stein M, Diezemann C, Sefrin A, Babel N, Reinke P. 2011. BK virus-specific immunity kinetics: a predictor of recovery from polyomavirus BK-associated nephropathy. Am J Transplant. 11(11):2443-52.

Schmitt A, Tonn T, Busch DH, Grigoleit GU, Einsele H, Odendahl M, Germeroth L, Ringhoffer M, Ringhoffer S, Wiesneth M, Greiner J, Michel D, Mertens T, Rojewski M, Marx M, von Harsdorf S, Dohner H, Seifried E, Bunjes D, Schmitt M. 2011. Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation. Transfusion. 51:591-599.

Thiel U, Pirson S, Muller-Spahn C, Conrad H, Busch DH, Bernhard H, Burdach S, Richter GH. 2011. Specific recognition and inhibition of Ewing tumour growth by antigen-specific allo-restricted cytotoxic T cells. Br J Cancer. 104:948-956.

Todorova K, Schulze H, Ciroki J, Uharek L, Salama A & Schönemann C. 2011. A new HLA-B*52 allele, B*52:23, detected in a patient before bone marrow transplantation. Tissue Antigens. 78:455–456.

Trydzenskaya H, Sattler A, Müller K, Schachtner T, Dang-Heine C, Friedrich P, Nickel P, Hoerstrup J, Schindler R, Thiel A, Melzig MF, Reinke P, Babel N. 2011. Novel approach for improved assessment of phenotypic and functional characteristics of BKV-specific T-cell immunity. Transplantation. 92(11):1269-77.

Westermann J, Flörcken A, Willimsky G, van Lessen A, Kopp J, Takvorian A, Jöhrens K, Lukowsky A, Schönemann C, Sawitzki B, Pohla H, Frank R, Dörken B, Schendel D, Blankenstein Th, Pezzutto A. 2011. Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer - a clinical phase-I study. Gene therapy. 18:354-363.

 

 

2010

Albrecht I, Niesner U, Janke M, Menning A, Loddenkemper C, Kühl AA, Lepenies I, Lexberg MH, Westendorf K, Hradilkova K, Grün J, Hamann A, Epstein JA, Chang HD, Tokoyoda K, Radbruch A. 2010. Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol. 40:2993.

Beckhove P, Warta R, Lemke B, Stoycheva D, Momburg F, Schnölzer M, Warnken U, Schmitz-Winnenthal H, Ahmadi R, Dyckhoff G, Bucur M, Jünger S, Schueler T, Lennerz V, Woelfel T, Unterberg A, Herold-Mende C. 2010. Rapid T cell-based identification of human tumor tissue antigens by automated two-dimensional protein fractionation. J Clin Invest. 120:2230.

Bendle GM, Linnemann C, Hooijkaas AI, de Witte MA, Jorritsma A, Bies L, Kaiser ADM, Pouw N, Debets R, Kieback E, Uckert W, Song JY, Haanen JBAG, Schumacher TNM. 2010. Lethal Graft-versus-host disease in mouse models of T cell receptor gene therapy. Nature Med. 16:565.

Bergbauer M, Kalla M, Schmeinck A, Göbel C, Rothbauer U, Eck S, Benet-Pagès A, Strom TM, Hammerschmidt W. 2010. CpG-methylation regulates a class of Epstein-Barr virus promoters. PLoS Pathog. 23:6.

Bethge WA, Lange T, Meisner C, Harsdorf von S, Bornhaeuser M, Federmann B, Stadler M, Uharek L, Stelljes M, Knop S, Wulf G, Trenschel R, Vucinic V, Dittmann H, Faul C, Vogel W, Kanz L & Bunjes D. Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced- intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase 2 study. Blood. 116:1795–1802.

Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T. 2010. TAK1 suppresses a NEMO-dependent, but NF-kB independent pathway to liver cancer. Cancer Cell. 17:481-96.

Briesemeister D, Sommermeyer D, Loddenkemper C, Loew R, Uckert W, Blankenstein Th, Kammertoens T. 2010. Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis. Int J Cancer.128:371.

Buchner A, Pohla H, Willimsky G, Frankenberger B, Frank R, Baur-Melnyk A, Siebels M, Stief C, Hofstetter A, Kopp J, Pezzutto A, Blankenstein Th, Oberneder R, Schendel DJ. 2010. Phase I trial of an allogeneic gene-modified tumor cell vaccine (RCC-26/CD80/IL-2) in patients with metastatic renal cell carcinoma. Hum Gene Ther. 21:285-297.

Büning H, Uckert W, Cichutek K, Hawkins RE, Abken H. 2010. Do CARs need a driver license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events. Hum Gene Ther. 21:1.

Bürdek M, Spranger S, Wilde S, Frankenberger B, Schendel DJ, Geiger C. 2010. Three-day dendritic cells for vaccine development: Antigen uptake, processing and presentation. J Transl Med. 8:90.

Buschow C, Charo J, Anders K, Loddenkemper C, Jukica A, Alsamah W, Perez C, Willimsky G, Blankenstein Th. 2010. In vivo imaging of an inducible oncogenic tumor antigen visualizes tumor progression and predicts CTL tolerance. J Immunol. 184:2930-2938.

Czeh M, Loddenkemper C, Shalapour S, Schön C, Robine S, Goldscheid E, Stein H, Schüler T, Willimsky G, Blankenstein Th. 2010. The immune response to sporadic colorectal cancer in a novel mouse model. Oncogene. 29:6591-6602.

Czéh M, Loddenkemper C, Shalapour S, Schön S, Robine S, Goldscheid E, Stein H, Schüler T, Willimsky G and Blankenstein Th. 2010. A sporadic antigenic colorectal cancer model based on rare stochastic, tissue-specific activation of a dormant SV40 T antigen. Oncogene. 29:6591-6602.

Dreger P, Döhner H, Ritgen M, Böttcher S, Busch R, Dietrich S, Bunjes D, Cohen S, Schubert J, Hegenbart U, Beelen D, Zeis M, Stadler M, Hasenkamp J, Uharek L, Scheid C, Humpe A, Zenz T, Winkler D, Hallek M, Kneba M, Schmitz N, Stilgenbauer S, German CLL Study Group. 2010. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood. 116:2438–2447.

Guerreiro M, Na IK, Letsch A, Haase D, Bauer S, Meisel C, Roemhild A, Reinke P, Volk HD, Scheibenbogen C. 2010. Human peripheral blood and bone marrow Epstein-Barr virus-specific T-cell repertoire in latent infection reveals distinct memory T-cell subsets. Eur J Immunol. 40(6):1566-76.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity. 32:116.

Heimesaat MM, Nogai A, Bereswill S, Plickert R, Fischer A, Loddenkemper C, Steinhoff U, Tchaptchet S, Thiel E, Freudenberg MA, Göbel UB & Uharek L. 2010. MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut. 59:1079–1087.

Iskra S, Kalla M, Delecluse HJ, Hammerschmidt W, Moosmann A. 2010. Toll-like receptor agonists synergistically increase proliferation and activation of B cells by Epstein-Barr virus. J Virol. 84:3612.

Juelke K, Killig M, Luetke-Eversloh M, Parente E, Gruen J, Morandi B, Ferlazzo G, Thiel A, Schmitt-Knosalla I, Romagnani C. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. 2010. Blood. 116:1299.

Kalla M, Schmeinck A, Bergbauer M, Pich D, Hammerschmidt W. 2010.  AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. Proc Natl Acad Sci U S A. 
107:850.

Kieback E, Uckert W. 2010.  Enhanced T cell receptor gene therapy for cancer. Expert Opin Biol Ther. 10:749.

Leisegang M, Turqueti-Neves A, Engels B, Blankenstein Th, Schendel DJ, Uckert W, Noessner E. 2010. T cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T cell therapy. Clin Cancer Res.  16:2333-2343.

Leisegang M, Wilde S, Milosevic S, Spranger S, Frankenberger B, Uckert W, Schendel DJ. 2010.  MHC-restricted fratricide of recipient lymphocytes expressing transgenic T cell receptors specific for the apoptosis-inhibitor protein survivin. J Clin Invest. 120:3869.

Lexberg MH, Taubner A, Albrecht I, Lepenies I, Richter A, Kamradt T, Radbruch A, Chang HD. 2010.  IFN-γand IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells. Eur J Immunol. 40:3017.

Li LP, Lampert C, Chen X, Leitao C, Popovic J, Müller W, Blankenstein Th. 2010. Trangenic mice with a diverse human T-cell antigen receptor repertoire. Nat Med. 16:1029-1034.

Liang X, Weigand LU, Schuster IG,  Eppinger E,  van der Griendt JC, Schub A, Leisegang M, Sommermeyer D, Anderl F,  Han Y, Ellwart J, Moosmann A, Busch DH, Uckert W, Peschel C, Krackhardt AM. 2010. A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire. J Immunol. 184:1617.

Meyerhuber P, Conrad H, Stärck L, Leisegang M, Busch DH, Uckert W, Bernhard H. 2010. Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes. J Mol Med. 88:1113.

Mishto M, Bellavista E, Ligorio C, Textoris-Taube K, Santoro A, Giordano M, D’Alfonso S, Listi F, Nacmias B, Cellini E, Leone M, Grimaldi LME, Fenoglio C, Esposito F, Martinelli-Boneschi F, Galimberti D, Scarpini E, Seifert U, Amato MP, Caruso C, Foschini MP, Kloetzel PM, Franceschi C. 2010. Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population. PLOS One.
5(2):e9287.

Moosmann A, Bigalke I, Tischer J, Schirrmann L, Kasten J, Tippmer S, Leeping M, Prevalsek D, Jaeger G, Ledderose G, Mautner J, Hammerschmidt W, Schendel DJ, Kolb HJ. 2010. Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells. Blood. 115:2960.

Nahmod K, Gentilini C, Vermeulen M, Uharek L, Wang Y, Zhang J, Schultheiss HP, Geffner J & Walther T. 2010. Impaired function of dendritic cells deficient in angiotensin II type 1 receptors. 2010. J Pharmacol Exp Ther. 334:854–862.

Neuenhahn M, Schiemann M, Busch DH. 2010. DCs in mouse models of intracellular bacterial infection. Methods Mol Biol. 595-319.

Neves P, Lampropoulou V, Calderon-Gomez E, Roch T, Stervbo U, Shen P, Kühl AA, Loddenkemper C, Haury M, Nedospasov SA, Kaufmann SH, Steinhoff U, Calado DP, Fillatreau S. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity. 33:777.

Norell H, Poschke I, Charo J, Wei WZ, Erskine C, Piechocki MP, Knutson KL, Bergh J, Lidbrink E, Kiessling R. 2010. Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial. J Transl Med. 8:53.

Oelert T, Papatriantafyllou M, Pougialis G, Hämmerling GJ, Arnold B, Schüler T. 2010. Irradiation and IL-15 promote loss of CD8 T-cell tolerance in response to lymphopenia. Blood. 115:2196.

Romagnani C. 2010. Conference Scene: Autoimmunity and transplantation: basic science and clinic translation meet in Geneva. 9th International Conference on New Trends in Immunosuppression and Immunotherapy 4-6 February, Geneva, Switzerland. Immunotherapy. 2:447.

Schmidt-Hieber M, Blau IW, Richter G, Türkmen S, Bommer C, Thiel G, Neitzel H, Stroux A, Uharek L, Thiel E & Blau O. 2010. Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation. Cancer Genet Cytogenet. 198:135–143.

Schmidt-Hieber M, Schwarck S, Stroux A, Ganepola S, Reinke P, Thiel E, Uharek L & Blau IW. 2010. Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion. Int J Hematol. 91:877–885.

Seifert U, Bialy LP, Ebstein F, Bech-Otshir D, Voigt A, Schroeter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E. 2010. Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell. 142:613.

Sercan O, Stoycheva D, Hämmerling GJ, Arnold B, Schüler T. 2010. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol. 184:2855.

Seto E, Moosmann A, Gromminger S, Walz N, Grundhoff A, Hammerschmidt W. 2010. Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. PLoS Pathog. 6:e1001063.

Shalapour S, Deiser K, Sercan Ö, Tuckermann J, Minnich K, Willimsky G, Blankenstein Th, Hämmerling G, Arnold B, Schüler T. 2010. Commensal microflora and interferon-g promote steady-state interleukin-7 production in vivo. Eur J Immunol. 40(9):2391-400.

Shalapour S, Eckert C, Seeger K, Pfau M, Prada J, Henze G, Blankenstein Th, Kammertoens T. 2010. Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia. J Mol Med.  88:249-265.

Shalapour S, Deiser K, Sercan Ö, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hämmerling GJ, Arnold B and Schüler T. 2010. The commensal microflora and Interferon-γ promote steady state Interleukin-7 production in vivo. Eur J Immunol. 40:2391-2400.

Sommermeyer D, Uckert W. 2010. Minimal amino acid exchange in human T cell receptor (TCR) constant regions fosters improved function of TCR gene-modified T cells. J Immunol. 184:6223.

Spranger S, Javorovic M, Bürdek M, Wilde S, Mosetter B, Tippmer S, Bigalke I, Geiger C, Schendel DJ, Frankenberger B. 2010. Generation of T helper-1 polarizing dendritic cells using the Toll-like receptor 7/8 agonist CL075. J Immunol. 185:738.

Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF. 2010. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol. 11:1057.

Tokoyoda K, Hauser AE, Nakayama T, Radbruch A. 2010. Organization of immunological memory by bone marrow stroma. Nat Rev Immunol. 10:193.

Yoshida T, Mei H, Dörner T, Hiepe F, Radbruch A, Fillatreau S, Hoyer BF. 2010. Memory B and memory plasma cells. Immunol Rev. 237:117.

Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer PH, Opferman JT, Galle PR, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H. 2010. Hepatocyte-specific deletion of the anti-apoptotic protein Mcl-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology. 51:1226-36. doi: 10.1002/hep.23479

Westermann J, Flörcken A, Willimsky G, van Lessen A, Kopp J,Takvorian A, Jöhrens K, Lukowsky A, Schönemann C, Sawitzki B, Pohla H,  Frank R, Dörken B, Schendel DJ, Blankenstein T and Pezzutto A. 2010. Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer – a clinical phase-I study. Gene Ther. 18:354-363.

 

2009

Alexander T, Thiel A, Rosen O, Massenkeil G, Sattler A, Kohler S, Mei H, Radtke H, Gromnica-Ihle E, Burmester GR, Arnold R, Radbruch A, Hiepe F. 2009. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood.113:214-23.

Babel N, Brestrich G, Gondek LP, Sattler A, Wlodarski MW, Poliak N, Bethke N, Thiel A, Hammer MH, Reinke P, Maciejewski JP. 2009. Clonotype analysis of cytomegalovirus-specific cytotoxic T lymphocytes. J Am Soc Nephrol. 20: 344.

Conrad C, Niess H, Huss R, Huber S, von Luettichau I, Nelson PJ, Ott HC, Jauch KW, Bruns CJ. 2009. Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation. 119:281.

Djafarzadeh R, Milani V, Rieth N, von Luettichau I, Skrablin PS, Hofstetter M, Noessner E, Nelson PJ. 2009. TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis. Cancer Immunol Immunother. 58:361.

Ebelt K, Babaryka G, Frankenberger B, Stief CG, Eisenmenger W, Kirchner T, Schendel DJ, Noessner E. 2009. Prostate cancer lesions are surrounded by FOXP3(+), PD-1(+) and B7-H1(+) lymphocyte clusters. Eur J Cancer. 45(9):1664-72.

Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Morth C, Naton B, Noth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schable K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershauser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Muller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabe de Angelis M. 2009. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 10:236.

Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Ferwagner B, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Morth C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B, Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Elisabeth Kremmer TK, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, de Angelis MH. 2009. Systemic first-line phenotyping. Methods Mol Biol. 530:463.

Geiger C, Nossner E, Frankenberger B, Falk CS, Pohla H, Schendel DJ. 2009. Harnessing innate and adaptive immunity for adoptive cell therapy of renal cell carcinoma. J Mol Med. 87(6)595-612.

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschlager N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J. 2009. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature.

Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D, Adler T, de Angelis MH, Irgang M, Otto C, Noppinger PR. 2009. Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology. 150:1722.

Kastenmuller W, Gasteiger G, Stross L, Busch DH, Drexler I. 2009. Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens. J Immunol. 182:2573.

Kelly GL, Long HM, Stylianou J, Thomas WA, Leese A, Bell AI, Bornkamm GW, Mautner J, Rickinson AB, Rowe M. 2009. An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link. PLoS Pathog. 5, e1000341.

Klibi J, Niki T, Riedel A, Pioche-Durieu C, Souquere S, Rubinstein E, Moulec SL, Guigay J, Hirashima M, Guemira F, Adhikary D, Mautner J, Busson P. 2009. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood. 113:1957.

Kohler S, Thiel A. 2009. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 113:769.

Kumar D, Hosse J, von Toerne C, Noessner E, Nelson PJ. 2009. JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1. J Immunol. 182:1011.

Markoullis K, Bulian D, Holzlwimmer G, Quintanilla-Martinez L, Heiliger KJ, Zitzelsberger H, Scherb H, Mysliwietz J, Uphoff CC, Drexler HG, Adler T, Busch DH, Schmidt J, Mahabir E. 2009. Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline transmission and chimeric progeny. Transgenic Res. 18:71.

Neuhierl B, Feederle R, Adhikary D, Hub B, Geletneky K, Mautner J, Delecluse HJ. 2009. Primary B-cell infection with a deltaBALF4 Epstein-Barr virus comes to a halt in the endosomal compartment yet still elicits a potent CD4-positive cytotoxic T-cell response. J Virol. 83:4616.

Nickel P, Bold G, Presber F, Biti D, Babel N, Kreutzer S, Pratschke J, Schonemann C, Kern F, Volk HD, Reinke P. 2009. High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function. Transpl Immunol. 20:238.

Pandya MJ, Bendz H, Manzenrieder F, Noessner E, Kessler H, Buchner J, Issels RD. 2009. Interaction of human heat shock protein 70 with tumor-associated peptides. Biol Chem. 390:305.

Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmermann HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR. 2009. Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. Kidney Int. 75:185.

Sattler A, Wagner U, Rossol M, Sieper J, Wu P, Krause A, Schmidt WA, Radmer S, Kohler S, Romagnani C, Thiel A. 2009. Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. Blood. 113:1948.

Schnurr M, Orban M, Robson NC, Shin A, Braley H, Airey D, Cebon J, Maraskovsky E, Endres S. 2009. ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II. J Immunol. 182:1253.

Stumpf AN, Schmidt C, Hiddemann W, Gerbitz A. 2009. High serum concentrations of cyclosporin related to administration of tigecycline. Eur J Clin Pharmacol. 65:101.

Uckert W, Schumacher TN. 2009. TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008. Cancer Immunol Immunother. 58:809.

Vertuani S, Triulzi C, Roos AK, Charo J, Norell H, Lemonnier F, Pisa P, Seliger B, Kiessling R. 2009. HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice. Cancer Immunol Immunother. 58:653.

Wolf S A, Steiner B, Akpinarli A, Kammertoens T, Nassenstein C, Braun A, Blankenstein T, Kempermann G. 2009. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol. 182:3979.

Wurzenberger C, Koelzer VH, Schreiber S, Anz D, Vollmar AM, Schnurr M, Endres S, Bourquin C. 2009. Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo. Cancer Immunol Immunother. 58:901.

 

2008

Abe K, Wechs S, Kalaydjiev S, Franz TJ, Busch DH, Fuchs H, Soewarto D, Behrendt H, Wagner S, Jakob T, Hrabe de Angelis M. 2008. Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice. Rheumatology. (Oxford) 47:292.

Adhikary D, Behrends U, Feederle R, Delecluse HJ, Mautner J. 2008. Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particles. J Virol. 82:3903.

Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ. 2008. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol. 38:3487.

Bendz H, Marincek BC, Momburg F, Ellwart JW, Issels RD, Nelson PJ, Noessner E. 2008. Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation. J Biol Chem. 283:26477.

Bernhard H, Neudorfer J, Gebhard K, Conrad H, Hermann C, Nahrig J, Fend F, Weber W, Busch DH, Peschel C. Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer. Cancer Immunol Immunother. 57:271.

Bleifuss E, Bendz H, Sirch B, Thompson S, Brandl A, Milani V, Graner MW, Drexler I, Kuppner M, Katsanis E, Noessner E, Issels RD. 2008. Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens. Int J Hyperthermia. 24:623.

Bourquin C, van der Haar ME, Anz D, Sandholzer N, Neumaier I, Endres S, Skerra A, Schwab ME, Linington C. 2008. DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis. Eur J Pharmacol. 588:99.

Bourquin C, Anz D, Zwiorek K, Lanz AL, Fuchs S, Weigel S, Wurzenberger C, von der Borch P, Golic M, Moder S, Winter G, Coester C, Endres S. 2008. Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity. J Immunol. 181:2990.

Brunner S, Huber BC, Fischer R, Groebner M, Hacker M, David R, Zaruba MM, Vallaster M, Rischpler C, Wilke A, Gerbitz A, Franz WM. 2008. G-CSF treatment after myocardial infarction: impact on bone marrow-derived vs cardiac progenitor cells. Exp Hematol. 36:695.

Conrad H, Gebhard K, Kronig H, Neudorfer J, Busch DH, Peschel C, Bernhard H. 2008. CTLs directed against HER2 specifically cross-react with HER3 and HER4. J Immunol. 180:8135.

Conrad C, Zeindl-Eberhart E, Moosmann S, Nelson PJ, Bruns CJ, Huss R. 2008. Alkaline phosphatase, glutathione-S-transferase-P, and cofilin-1 distinguish multipotent mesenchymal stromal cell lines derived from the bone marrow versus peripheral blood. Stem Cells Dev. 17:23.

Dauer M, Lam V, Arnold H, Junkmann J, Kiefl R, Bauer C, Schnurr M, Endres S, Eigler A. 2008. Combined use of toll-like receptor agonists and prostaglandin E(2) in the FastDC model: rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production. J Immunol Methods. 337:97.

Delecluse HJ, Feederle R, Behrends U, Mautner J. 2008. Contribution of viral recombinants to the study of the immune response against the Epstein-Barr virus. Semin Cancer Biol. 18:409.

Ebelt K, Babaryka G, Figel AM, Pohla H, Buchner A, Stief CG, Eisenmenger W, Kirchner T, Schendel DJ, Noessner E. 2008. Dominance of CD4+ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma. Prostate. 68:1.

Frenzel LP, Abdullah Z, Kriegeskorte AK, Dieterich R, Lange N, Busch DH, Kronke M, Utermohlen O, Hescheler J, Saric T. 2008. Role of NKG2D-ligands and ICAM-1 in NK cell-mediated Lysis of Murine Embryonic Stem Cells and Embryonic Stem Cell-derived Cardiomyocytes. Stem Cells.

Fuhrmann S, Streitz M, Reinke P, Volk HD, Kern F. 2008. T cell response to the cytomegalovirus major capsid protein (UL86) is dominated by helper cells with a large polyfunctional component and diverse epitope recognition. J Infect Dis. 197:1455.

Gerbitz A, Hillemanns P, Schmid C, Wilke A, Jayaraman R, Kolb HJ, Eissner G, Holler E. 2008. Influence of polymorphism within the heme oxygenase-I promoter on overall survival and transplantation-related mortality after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 14:1180.

Grau SJ, Trillsch F, von Luttichau I, Nelson PJ, Herms J, Tonn JC, Goldbrunner RH. 2008. Lymphatic phenotype of tumour vessels in malignant gliomas. Neuropathol Appl Neurobiol. 34:675.

Heit A, Gebhardt F, Lahl K, Neuenhahn M, Schmitz F, Anderl F, Wagner H, Sparwasser T, Busch DH, Kastenmuller K. 2008. Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol. 38:1585.

Javorovic M, Wilde S, Zobywalski A, Noessner E, Lennerz V, Wolfel T, Schendel DJ. 2008. Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells. J Immunother. 31:52.

Kammertoens T, Blankenstein Th. 2008. Making and circumventing tolerance to cancer. Eur J Immunol. 39:2345-53.

Kieback E, Charo J, Sommermeyer D, Blankenstein Th, Uckert W. 2008. A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer. Proc Natl Acad Sci U S A. 105:623.

Kirchner A, Hoffmeister B, Cherepnev GG, Fuhrmann S, Streitz M, Lachmann R, Bunde T, Meij P, Schonemann C, Hetzer R, Lehmkuhl HB, Volkmer-Engert R, Volk HD, Gratama JW, Kern F. 2008. Dissection of the CMV specific T-cell response is required for optimized cardiac transplant monitoring. J Med Virol. 80:1604.

Kronenberger K, Nossner E, Frankenberger B, Wahl U, Dreyling M, Hallek M, Mocikat R. 2008. A polyvalent cellular vaccine induces T-cell responses against specific self-antigens overexpressed in chronic lymphocytic B-cell leukemia. J Immunother. 31:723.

Kruschinski A, Moosmann A, Poschke I, Norell H, Chmielewski M, Seliger B, Kiessling R, Blankenstein Th, Abken H, Charo J. 2008. Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas. Proc Natl Acad Sci U S A. 105:17481.

Kuppner MC, Bleifuss E, Noessner E, Mocikat R, Hesler C, Mayerhofer C, Issels RD. 2008. Differential effects of ifosfamide on dendritic cell-mediated stimulation of T cell interleukin-2 production, natural killer cell cytotoxicity and interferon-gamma production. Clin Exp Immunol.153:429.

Kuprash DV, Qin Z, Ito D, Grivennikov SI, Abe K, Drutskaya LN, Blankenstein Th, Nedospasov S A. 2008. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice. Cancer Lett. 268:70.

Lampropoulou V, Calderon-Gomez E, Roch T, Neves P, Shen P, Stervbo U, Boudinot P, Anderton SM, Fillatreau S. 2008. Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity. Immunol Rev. 233:146.

Leisegang M, Engels B, Meyerhuber P, Kieback E, Sommermeyer D, Xue S A, Reuss S, Stauss H, Uckert W. 2008. Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette. J Mol Med. 86:573.

Li L, Willimsky G, Seitz S, Xu Y, Li Y, Schwarz LE, Schlag PM, Blankenstein Th. 2008. SV40 large T antigen-transformed human primary normal and cancerous mammary epithelial cells are phenotypically similar but can be distinguished in 3D culture with selection medium. Int J Cancer. 123:1516.

Lochner M, Kastenmuller K, Neuenhahn M, Weighardt H, Busch DH, Reindl W, Forster I. 2008. Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18. Infect Immun. 76:3881.

Luking C, Kronenberger K, Frankenberger B, Noessner E, Rocken M, Mocikat R. 2008. Antitumor effector functions of T cells are dependent on in vivo priming and restricted T-cell receptor expression. Int J Cancer. 122:2280.

Meier S, Stark R, Frentsch M, Thiel A. 2008. The influence of different stimulation conditions on the assessment of antigen-induced CD154 expression on CD4+ T cells. Cytometry A. 73:1035.

Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya S S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Hacker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tuting T, Hartmann G. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med. 14:1256.

Riedel A, Nimmerjahn F, Burdach S, Behrends U, Bornkamm GW, Mautner J. 2008. Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export. Eur J Immunol. 38:2090.

Sakowicz-Burkiewicz M, Nishanth G, Helmuth U, Drogemuller K, Busch DH, Utermohlen O, Naumann M, Deckert M, Schluter D. 2008. Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J Immunol. 180:5601.

Sawitzki B, Reinke P, Volk HD, Wood K, Turka LA. 2008. Autoimmunity and transplantation: a meeting at the crossroads in Berlin. Nat Immunol. 9:447.

Schlosser E, Mueller M, Fischer S, Basta S, Busch DH, Gander B, Groettrup M. 2008. TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. Vaccine. 26:1626.

Schmid C, Schleuning M, Hentrich M, Markl GE, Gerbitz A, Tischer J, Ledderose G, Oruzio D, Hiddemann W, Kolb HJ. 2008. High antileukemic efficacy of an intermediate intensity conditioning regimen for allogeneic stem cell transplantation in patients with high-risk acute myeloid leukemia in first complete remission. Bone Marrow Transplant. 41:721.

Segerer S, Heller F, Lindenmeyer MT, Schmid H, Cohen CD, Draganovici D, Mandelbaum J, Nelson PJ, Grone HJ, Grone EF, Figel AM, Noessner E, Schlondorff D. 2008. Compartment specific expression of dendritic cell markers in human glomerulonephritis. Kidney Int. 74:37.

Sewald X, Gebert-Vogl B, Prassl S, Barwig I, Weiss E, Fabbri M, Osicka R, Schiemann M, Busch DH, Semmrich M, Holzmann B, Sebo P, Haas R. 2008. Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. Cell Host Microbe. 3:20.

Shin A, Toy T, Rothenfusser S, Robson N, Vorac J, Dauer M, Stuplich M, Endres S, Cebon J, Maraskovsky E, Schnurr M. 2008. P2Y receptor signaling regulates phenotype and IFN-alpha secretion of human plasmacytoid dendritic cells. Blood. 111:3062.

von Luettichau I, Segerer S, Wechselberger A, Notohamiprodjo M, Nathrath M, Kremer M, Henger A, Djafarzadeh R, Burdach S, Huss R, Nelson PJ. 2008. A complex pattern of chemokine receptor expression is seen in osteosarcoma. BMC Cancer. 8:23.

Walzlein JH, Synowitz M, Engels B, Markovic DS, Gabrusiewicz K, Nikolaev E, Yoshikawa K, Kaminska B, Kempermann G, Uckert, W, Kaczmarek L, Kettenmann H, Glass R. 2008. The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells. 26:2945.

Weingart C, Nelson PJ, Kramer BK, Mack M. 2008. Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells. BMC Immunol. 9:72.

Wiesner M, Zentz C, Mayr C, Wimmer R, Hammerschmidt W, Zeidler R, Moosmann A. 2008. Conditional immortalization of human B cells by CD40 ligation. PLoS ONE. 3:e1464.

Willimsky G, Czeh M, Loddenkemper C, Gellermann J, Schmidt K, Wust P, Stein H, Blankenstein Th. 2008. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med.  205:1687.

Witter K, Mautner J, Volgger A, Zahn R, Kauke T. 2008. A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line. Tissue Antigens. 71:257.

Zwiorek K, Bourquin C, Battiany J, Winter G, Endres S, Hartmann G, Coester C. 2008. Delivery by cationic gelatin nanoparticles strongly increases the immunostimulatory effects of CpG oligonucleotides. Pharm Res. 25:551.

 

2007

Adhikary D, Behrends U, Boerschmann H, Pfunder A, Burdach S, Moosmann A, Witter K, Bornkamm GW, Mautner J. 2007. Immunodominance of lytic cycle antigens in epstein-barr virus-specific CD4+ T cell preparations for therapy. PLoS ONE. 2:e583.

Agger R, Petersen MS, Petersen CC, Hansen SB, Stodkilde-Jorgensen H, Skands U, Blankenstein Th, Andersen TE, Hulgaard EF, Jorgensen JT, Marqversen J, Gundersen HJ, Hokland ME. 2007. T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging. J Immunother. 30:29.

Allgeier T, Garhammer S, Noessner E, Wahl U, Kronenberger K, Dreyling M, Hallek M, Mocikat R. 2007. Dendritic cell-based immunogens for B-cell chronic lymphocytic leukemia. Cancer Lett. 245:275.

Bauer C, Loher F, Dauer M, Mayer C, Lehr HA, Schonharting M, Hallwachs R, Endres S, Eigler A. 2007. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig Dis Sci. 52:1642.

Bauer C, Bauernfeind F, Sterzik A, Orban M, Schnurr M, Lehr HA, Endres S, Eigler A, Dauer M. 2007. Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. Gut. 56: 1275.

Bekeredjian-Ding I, Inamura S, Giese T, Moll H, Endres S, Sing A, Zahringer U, Hartmann G. 2007. Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands. J Immunol 178: 2803.

Bendz H, Ruhland SC, Pandya MJ, Hainzl O, Riegelsberger S, Brauchle C, Mayer MP, Buchner J, Issels RD, Noessner E. 2007. Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling. J Biol Chem. 282:31688.

Blankenstein Th. 2007. Do autochthonous tumors interfere with effector T cell responses? Semin Cancer Biol. 17:267.

Bourquin C, Schmidt L, Hornung V, Wurzenberger C, Anz D, Sandholzer N, Schreiber S, Voelkl A, Hartmann G, Endres S. 2007. Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response. Blood. 109:2953.

Brill TH, Kubler HR, von Randenborgh H, Fend F, Pohla H, Breul J, Hartung R, Paul R, Schendel DJ, Gansbacher B. 2007. Allogeneic retrovirally transduced, IL-2- and IFN-gamma-secreting cancer cell vaccine in patients with hormone refractory prostate cancer--a phase I clinical trial. J Gene Med. 9:547.

Cayeux S, Bukarica B, Buschow C, Charo J, Bunse M, Dorken B, Blankenstein Th. 2007. In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine. Gene Ther. 14:1481.

Charo J, Robbins PF. 2007. Contrasting effects of FLIPL overexpression in human T cells on activation-induced cell death and cytokine production. J Leukoc Biol. 81:1297.

Conrad C, Gupta R, Mohan H, Niess H, Bruns CJ, Kopp R, von Luettichau I, Guba M, Heeschen C, Jauch KW, Huss R, Nelson PJ. 2007. Genetically engineered stem cells for therapeutic gene delivery. Curr Gene Ther. 7:249.

Cosma A, Nagaraj R, Staib C, Diemer C, Wopfner F, Schatzl H, Busch DH, Sutter G, Goebel FD, Erfle V. 2007. Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART. AIDS Res Hum Retroviruses. 23:782.

Engels B, Uckert W. 2007. Redirecting T lymphocyte specificity by T cell receptor gene transfer--a new era for immunotherapy. Mol Aspects Med. 28:115.

Ewing P, Hildebrandt GC, Planke S, Andreesen R, Holler E, Gerbitz A. 2007. Cobalt protoporphyrine IX-mediated heme oxygenase-I induction alters the inflammatory cytokine response, but not antigen presentation after experimental allogeneic bone marrow transplantation. Int J Mol Med. 20:301.

Frankenberger B, Noessner E, Schendel DJ. 2007. Immune suppression in renal cell carcinoma. Semin Cancer Biol. 17:330.

Gamrekelashvili J, Kruger C, von Wasielewski R, Hoffmann M, Huster KM, Busch DH, Manns MP, Korangy F, Greten TF. 2007. Necrotic tumor cell death in vivo impairs tumor-specific immune responses. J Immunol. 178:1573.

Grau SJ, Trillsch F, Herms J, Thon N, Nelson PJ, Tonn JC, Goldbrunner R. 2007. Expression of VEGFR3 in glioma endothelium correlates with tumor grade. J Neurooncol. 82:141.

Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Goktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. 2007. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 130:918.

Hamm S, Heit A, Koffler M, Huster KM, Akira S, Busch DH, Wagner H, Bauer S. 2007. Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. Int Immunol. 19:297.

Hammer MH, Brestrich G, Mittenzweig A, Roemhild A, Zwinger S, Subklewe M, Beier C, Kurtz A, Babel N, Volk HD, Reinke P. 2007. Generation of EBV-specific T cells for adoptive immunotherapy: a novel protocol using formalin-fixed stimulator cells to increase biosafety. J Immunother. 30:817.

Heit A, Schmitz F, Haas T, Busch DH, Wagner H. 2007. Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity. Eur J Immunol. 37:2063.

Kastenmuller W, Gasteiger G, Gronau JH, Baier R, Ljapoci R, Busch DH, Drexler I. 2007. Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J Exp Med. 204:2187.

Khalil PN, Weiler V, Nelson PJ, Khalil MN, Moosmann S, Mutschler WE, Siebeck M, Huss R. 2007. Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease. Gastroenterology. 132:944.

Krause M, Schmitz M, Noessner E, Skrablin PS, Wehner R, Rieber EP, Baumann M. 2007. Adoptive transfer of cytotoxic T-cells for treatment of residual disease after irradiation. Int J Radiat Biol. 83:827.

Landmeier S, Altvater B, Pscherer S, Juergens H, Varnholt L, Hansmeier A, Bollard CM, Moosmann A, Bisping G, Rossig C. 2007. Activated Human gammadelta T Cells as Stimulators of Specific CD8+ T-cell Responses to Subdominant Epstein Barr Virus Epitopes: Potential for Immunotherapy of Cancer. J Immunother. 32:310.

Lang S, Tiwari S, Andratschke M, Loehr I, Lauffer L, Bergmann C, Mack B, Lebeau A, Moosmann A, Whiteside TL, Zeidler R. 2007. Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. Cancer Immunol Immunother. 56:1645.

Letsch A, Knoedler M, Na IK, Kern F, Asemissen AM, Keilholz U, Loesch M, Thiel E, Volk HD, Scheibenbogen C. 2007. CMV-specific central memory T cells reside in bone marrow. Eur J Immunol. 37:3063.

Li Z, Pradera F, Kammertoens T, Li B, Liu S, Qin Z. 2007. Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection. J Immunol. 179:1568.

McNicol AM, Bendle G, Holler A, Matjeka T, Dalton E, Rettig L, Zamoyska R, Uckert W, Xue S A, Stauss HJ. 2007. CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR. Eur J Immunol. 37:1634.

Nassenstein C, Kammertoens T, Veres TZ, Uckert W, Spies E, Fuchs B, Krug N, Braun A. 2007. Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR. J Allergy Clin Immunol. 120:1089.

Neudorfer J, Schmidt B, Huster KM, Anderl F, Schiemann M, Holzapfel G, Schmidt T, Germeroth L, Wagner H, Peschel C, Busch DH, Bernhard H. 2007. Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. J Immunol Methods. 320:119.

Reuss S, Biese P, Cosset FL, Takeuchi Y, Uckert W. 2007. Suspension packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector particles. Gene Ther. 14:595.

Rubio-Aliaga I, Soewarto D, Wagner S, Klaften M, Fuchs H, Kalaydjiev S, Busch DH, Klempt M, Rathkolb B, Wolf E, Abe K, Zeiser S, Przemeck GK, Beckers J, de Angelis MH. 2007. A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics. 175:1451.

Schub A, Schuster IG, Hammerschmidt W, Moosmann A. 2007. CMV-specific TCR-transgenic T cells for immunotherapy. J Immunol. 183:6819.

Schulz C, Schafer A, Stolla M, Kerstan S, Lorenz M, von Bruhl ML, Schiemann M, Bauersachs J, Gloe T, Busch DH, Gawaz M, Massberg S. 2007. Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets. Circulation. 116:764.

Schuster IG, Busch DH, Eppinger E, Kremmer E, Milosevic S, Hennard C, Kuttler C, Ellwart JW, Frankenberger B, Noessner E, Salat C, Bogner C, Borkhardt A, Kolb HJ, Krackhardt AM. Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies. Blood. 110:2931.

Segerer S, Djafarzadeh R, Grone HJ, Weingart C, Kerjaschki D, Weber C, Kungl AJ, Regele H, Proudfoot AE, Nelson PJ. 2007. Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation. J Am Soc Nephrol. 18:1835.

Stemberger C, Huster KM, Koffler M, Anderl F, Schiemann M, Wagner H, Busch DH,.2007. A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets. Immunity. 27:985.

Weinhold M, Sommermeyer D, Uckert W, Blankenstein T. 2007. Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity. J Immunol. 179:5534.

Wiethe C, Schiemann M, Busch D, Haeberle L, Kopf M, Schuler G, Lutz MB. 2007. Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity. J Immunol. 178:4908.

Willimsky G, Blankenstein T. 2007. The adaptive immune response to sporadic cancer. Immunol Rev. 220:102.

Witter K, Mautner J, Albert T, Zahn R, Kauke T. 2007. HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102. Tissue Antigens. 70:73.

Zentz C, Wiesner M, Man S, Frankenberger B, Wollenberg B, Hillemanns P, Zeidler R, Hammerschmidt W, Moosmann A. 2007. Activated B cells mediate efficient expansion of rare antigen-specific T cells. Hum Immunol. 68:75.

 

 

2006

Adhikary D, Behrends U, Moosmann A, Witter K, Bornkamm GW, Mautner J. 2006. Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins. J Exp Med. 203:995.

Barrantes Idel B, Montero-Pedrazuela A, Guadano-Ferraz A, Obregon MJ, Martinez de Mena R, Gailus-Durner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Holter S, Rathkolb B, Reinhard C, Morreale de Escobar G, Bernal J, Busch D H, Wurst W, Wolf E, Schulz H, Shtrom S, Greiner E, Hrabe de Angelis M, Westphal H, Niehrs C. 2006. Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol. 26:2317.

Bekeredjian-Ding I, Roth SI, Gilles S, Giese T, Ablasser A, Hornung V, Endres S, Hartmann G. 2006. T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J Immunol. 176:7438.

Bleifuss E, Kammertoens T, Hutloff A, Quarcoo D, Dorner M, Straub P, Uckert W, Hildt E. 2006. The translocation motif of hepatitis B virus improves protein vaccination. Cell Mol Life Sci. 63:627.

Bourquin C, Schreiber S, Beck S, Hartmann G, Endres S. 2006. Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer. Int J Cancer. 118:2790.

Cohen CD, Klingenhoff A, Boucherot A, Nitsche A, Henger A, Brunner B, Schmid H, Merkle M, Saleem MA, Koller KP, Werner T, Grone HJ, Nelson PJ, Kretzler M. 2006. Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins. Proc Natl Acad Sci U S A. 103:5682.

Dauer M, Schad K, Junkmann J, Bauer C, Herten J, Kiefl R, Schnurr M, Endres S, Eigler A. 2006. IFN-alpha promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4. J Leukoc Biol. 80:278.

Djafarzadeh R, Noessner E, Engelmann H, Schendel DJ, Notohamiprodjo M, von Luettichau I, Nelson PJ. 2006. GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing. Oncogene. 25:1496.

Eigenbrod S, Derwand R, Jakl V, Endres S, Eigler A. 2006. Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. Immunol Invest. 35:149.

Endl J, Rosinger S, Schwarz B, Friedrich SO, Rothe G, Karges W, Schlosser M, Eiermann T, Schendel DJ, Boehm BO. 2006. Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes. 55:50.

Feederle R, Neuhierl B, Baldwin G, Bannert H, Hub B, Mautner J, Behrends U. 2006. Delecluse, H. J., Epstein-Barr virus BNRF1 protein allows efficient transfer from the endosomal compartment to the nucleus of primary B lymphocytes. J Virol. 80:9435.

Gvozdenovic BS, Zugic V, Lapcevic M, Vukovic M, Milosevic S, Plavsic S, Orlovic SZ. 2006. [Relationship between respiratory symptoms and satisfaction with inhaled asthma medication]. Srp Arh Celok Lek. 134:498.

Hammer MH, Brestrich G, Andree H, Engelmann E, Rosenberger C, Tillmann H, Zwinger S, Babel N, Nickel P, Volk HD, Reinke P. 2006. HLA type-independent method to monitor polyoma BK virus-specific CD4 and CD8 T-cell immunity. Am J Transplant. 6:625.

Hartmann E, Graefe H, Hopert A, Pries R, Rothenfusser S, Poeck H, Mack B, Endres S, Hartmann G, Wollenberg B. 2006. Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium. Clin Vaccine Immunol. 13:1278.

Hettich E, Janz A, Zeidler R, Pich D, Hellebrand E, Weissflog B, Moosmann A, Hammerschmidt W. 2006. Genetic design of an optimized packaging cell line for gene vectors transducing human B cells. Gene Ther. 13:844.

Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. 2006. 5'-Triphosphate RNA is the ligand for RIG-I. Science. 314:994.

Huster KM, Koffler M, Stemberger C, Schiemann M, Wagner H, Busch DH. 2006. Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells. Eur J Immunol. 36:1453.

Kerkmann M, Lochmann D, Weyermann J, Marschner A, Poeck H, Wagner M, Battiany J, Zimmer A, Endres S, Hartmann G. 2006. Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles. Oligonucleotides. 16:313.

Lang S, Picu A, Hofmann T, Andratschke M, Mack B, Moosmann A, Gires O, Tiwari S, Zeidler R. 2006. COX-inhibitors relieve the immunosuppressive effect of tumor cells and improve functions of immune effectors. Int J Immunopathol Pharmacol. 19:409.

Massberg S, Konrad I, Schurzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med. 203:1221.

Milani V, Noessner E. 2006. Effects of thermal stress on tumor antigenicity and recognition by immune effector cells. Cancer Immunol Immunother. 55:312.

Milosevic S, Behrends U, Adhikary D, Mautner J. 2006. Identification of major histocompatibility complex class II-restricted antigens and epitopes of the Epstein-Barr virus by a novel bacterial expression cloning approach. J Virol. 80:10357.

Neuenhahn M, Kerksiek KM, Nauerth M, Suhre MH, Schiemann M, Gebhardt FE, Stemberger C, Panthel K, Schroder S, Chakraborty T, Jung S, Hochrein H, Russmann H, Brocker T, Busch DH. 2006. CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity. 25:619.

Noessner E. 2006. Thermal stress-related modulation of tumor cell physiology and immune responses. Cancer Immunol Immunother. 55:289.

Notohamiprodjo M, Djafarzadeh R, Mojaat A, von Luttichau I, Grone HJ, Nelson PJ. 2006. Generation of GPI-linked CCL5 based chemokine receptor antagonists for the suppression of acute vascular damage during allograft transplantation. Protein Eng Des Sel. 19:27.

Osterloh P, Linkemann K, Tenzer S, Rammensee HG, Radsak MP, Busch DH, Schild H. 2006. Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci U S A. 103:5042.

Panthel K, Meinel KM, Sevil Domenech VE, Geginat G, Linkemann K, Busch DH, Russmann H. 2006. Prophylactic anti-tumor immunity against a murine fibrosarcoma triggered by the Salmonella type III secretion system. Microbes Infect. 8:2539.

Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE. 2006. Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood. 108:2942.

Schleypen JS, Baur N, Kammerer R, Nelson PJ, Rohrmann K, Grone EF, Hohenfellner M, Haferkamp A, Pohla H, Schendel DJ, Falk CS, Noessner E. 2006. Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma. Clin Cancer Res. 12:718.

Schmid H, Boucherot A, Yasuda Y, Henger A, Brunner B, Eichinger F, Nitsche A, Kiss E, Bleich M, Grone HJ, Nelson PJ, Schlondorff D, Cohen CD, Kretzler M. 2006. Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes. 55:2993.

Segerer S, Henger A, Schmid H, Kretzler M, Draganovici D, Brandt U, Noessner E, Nelson PJ, Kerjaschki D, Schlondorff D, Regele H. 2006. Expression of the chemokine receptor CXCR1 in human glomerular diseases. Kidney Int. 
69:1765.

Sommermeyer D, Neudorfer J, Weinhold M, Leisegang M, Engels B, Noessner E, Heemskerk MH, Charo J, Schendel DJ, Blankenstein Th, Bernhard H, Uckert W. 2006. Designer T cells by T cell receptor replacement. Eur J Immunol.  36:3052.

Volk HD, Sawitzki B, Kern F, Hoflich C, Sabat R, Reinke P. 2006. Immunomodulatory therapies: challenges of individualized therapy strategies. Ernst Schering Found Symp Proc. 59.

von Geldern M, Simm B, Braun M, Weiss EH, Schendel DJ, Falk CS. 2006. TCR-independent cytokine stimulation induces non-MHC-restricted T cell activity and is negatively regulated by HLA class I. Eur J Immunol. 36:2347.

von Luettichau I, Nathrath M, Burdach S, Huss R, Segerer S, Nelson PJ. 2006. Mononuclear infiltrates in osteosarcoma and chemokine receptor expression. Clin Cancer Res. 12:5253.

Wingender G, Garbi N, Schumak B, Jungerkes F, Endl E, von Bubnoff D, Steitz J, Striegler J, Moldenhauer G, Tuting T, Heit A, Huster KM, Takikawa O, Akira S, Busch DH, Wagner H, Hammerling GJ, Knolle PA, Limmer A. 2006. Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur J Immunol. 36:12.

 

 

 

 

 

 


SFB TR36 - Charité-Universitätsmedizin Berlin
Prof. Dr. Thomas Blankenstein
Institute of Immunology
Lindenberger Weg 80
13125 Berlin

SFB TR36 -Technische Universität München
Prof. Dr. Dirk Busch
Institute for Medical Microbiology, Immunology and Hygiene
Trogerstraße 30
81675 München